Abstract
Aitkens S, Kilmer DD, Wright NC, McCrory MA. Metabolic syndrome in neuromuscular disease.
Objectives
To test the hypotheses that (1) people with neuromuscular disease (NMD) have multiple
risk factors for cardiovascular disease and diabetes and (2) these risk factors worsen
over time.
Design
Longitudinal testing with average 2.5-year follow-up.
Setting
Human performance laboratory of a university.
Participants
Eleven ambulatory volunteers with slowly progressive NMD and 8 able-bodied controls,
group-matched for age and body mass index (BMI) at baseline.
Interventions
Not applicable.
Main outcome measures
Percentage of body fat (%BF), physical activity, energy expenditure, blood lipids
and glucose, and blood pressure.
Results
At baseline, NMD subjects were more obese (37%BF vs 34%BF, respectively) and more
sedentary than the controls, spending less time in total activity (144min/d vs 214min/d)
and in exercise (11min/d vs 45min/d). The NMD group also had numerous cardiovascular
and metabolic risk factors, with low high-density lipoprotein cholesterol, high BMI,
and high triglyceride being the most common. Additionally, 55% of the NMD group satisfied
the criteria for metabolic syndrome, versus 0% in the control group. Most parameters
did not significantly worsen during the average 2.5-year follow-up period in either
group.
Conclusions
People with NMD are at high risk for developing chronic diseases resulting from obesity
and a sedentary lifestyle. Intervention studies aimed at reducing their risk for such
chronic diseases are warranted.
Key words
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Article info
Footnotes
Supported by the National Institute on Disability and Rehabilitation Research, US Department of Education (grant nos. H133B031118, H133B980008).
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the author(s) or on any organization with which the author(s) is/are associated.
Identification
Copyright
© 2005 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
