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Articles| Volume 86, ISSUE 4, P697-702, April 2005

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Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain

      Abstract

      Topol GA, Reeves KD, Hassanein KM. Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain. Arch Phys Med Rehabil 2005;86: 697–702.

      Objective

      To determine the efficacy of simple dextrose prolotherapy in elite kicking-sport athletes with chronic groin pain from osteitis pubis and/or adductor tendinopathy.

      Design

      Consecutive case series.

      Setting

      Orthopedic and trauma institute in Argentina.

      Participants

      Twenty-two rugby and 2 soccer players with chronic groin pain that prevented full sports participation and who were nonresponsive both to therapy and to a graded reintroduction into sports activity.

      Intervention

      Monthly injection of 12.5% dextrose and 0.5% lidocaine into the thigh adductor origins, suprapubic abdominal insertions, and symphysis pubis, depending on palpation tenderness. Injections were given until complete resolution of pain or lack of improvement for 2 consecutive treatments.

      Main outcome measures

      Visual analog scale (VAS) for pain with sports and the Nirschl Pain Phase Scale (NPPS), a measure of functional impairment from pain.

      Results

      The final data collection point was 6 to 32 months after treatment (mean, 17mo). A mean of 2.8 treatments were given. The mean reduction in pain during sports, as measured by the VAS, improved from 6.3±1.4 to 1.0±2.4 (P<.001), and the mean reduction in NPPS score improved from 5.3±0.7 to 0.8±1.9 (P<.001). Twenty of 24 patients had no pain and 22 of 24 were unrestricted with sports at final data collection.

      Conclusions

      Dextrose prolotherapy showed marked efficacy for chronic groin pain in this group of elite rugby and soccer athletes.

      Key words

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      References

        • Holmich P.
        • Uhrskou P.
        • Ulnits L.
        • et al.
        Effectiveness of active physical training as treatment for long-standing adductor-related groin pain in athletes; randomized trial.
        Lancet. 1999; 353: 439-443
        • Andrews S.K.
        • Carek P.J.
        Osteitis pubis.
        J Am Board Fam Pract. 1998; 11: 291-295
        • Morelli V.
        • Smith V.
        Groin injuries in athletes.
        Am Fam Physician. 2001; 64: 1405-1414
        • Batt M.E.
        • McShane J.M.
        • Dillingham M.F.
        Osteitis pubis in collegiate football players.
        Med Sci Sports Exerc. 1995; 27: 629-633
        • Edwards S.G.
        • Calandruccio J.H.
        Autologous blood injections for refractory lateral epicondylitis.
        J Hand Surg [Am]. 2003; 28: 272-278
        • Paavola M.
        • Kannus P.
        • Jarvinen T.A.
        • Jarvinen T.L.
        • Jozsa L.
        • Jarvinen M.
        Treatment of tendon disorders. Is there a role for corticosteroid injection?.
        Foot Ankle Clin. 2002; 7: 501-513
        • Leadbetter W.B.
        Soft tissue athletic injury.
        in: Fu F.H. Sports injuries mechanisms, prevention, treatment. Williams & Wilkins, Baltimore1994: 736-737
        • Matsuda S.
        • Kondo M.
        • Mashima T.
        • Hoshino S.
        • Shinohara N.
        • Sumida S.
        Recombinant human erythropoietin therapy for autologous blood donation in rheumatoid arthritis patients undergoing total hip or knee arthroplasty.
        Orthopedics. 2001; 24: 41-44
        • Schmidmaier G.
        • Wildemann B.
        • Heeger J.
        • et al.
        Fracture healing with local injection of IGF-1 and TGFbeta1.
        Bone. 2002; 31: 165-172
        • Comerota A.J.
        • Throm R.C.
        • Miller K.A.
        • et al.
        Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end-stage unreconstructible lower extremity ischemia.
        J Vasc Surg. 2002; 35: 930-936
        • Nakamura N.
        • Shino K.
        • Natsuume T.
        • et al.
        Early biological effect of in vivo gene transfer of platelet-derived growth factor (PDGF)-B into healing patellar ligament.
        Gene Ther. 1998; 5: 1165-1170
        • Oh J.H.
        • Ha H.
        • Yu M.R.
        • Lee H.B.
        Sequential effects of high glucose on mesangial cell transforming growth factor-beta 1 and fibronectin synthesis.
        Kidney Int. 1998; 54: 1872-1878
        • Di Paolo S.
        • Gesualdo L.
        • Ranieri E.
        • Grandaliano G.
        • Schena F.P.
        High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells.
        Am J Pathol. 1996; 149: 2095-2106
        • Murphy M.
        • Godson C.
        • Cannon S.
        • et al.
        Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells.
        J Biol Chem. 1999; 274: 5830-5834
        • Fukuda K.
        • Kawata S.
        • Inui Y.
        • et al.
        High concentration of glucose increases mitogenic responsiveness to heparin-binding epidermal growth factor-like growth factor in rat vascular smooth muscle cells.
        Arterioscler Thromb Vasc Biol. 1997; 17: 1962-1968
        • Ohgi S.
        • Johnson P.W.
        Glucose modulates growth of gingival fibroblasts and periodontal ligament cells.
        J Periodontal Res. 1996; 31: 579-588
        • Pugliese G.
        • Pricci F.
        • Locuratolo N.
        • et al.
        Increased activity of the insulin-like growth factor system in mesangial cells cultured in high glucose conditions. Relation to glucose-enhanced extracellular matrix production.
        Diabetologia. 1996; 39: 775-784
        • Woo S.
        • Hildebrand K.
        • Watanabe N.
        • Fenwick J.
        • Papageorgiou C.
        • Wang J.
        Tissue engineering of ligament and tendon healing.
        Clin Orthop. 1999; (Oct(367 Suppl)): 312-314
        • Reeves K.D.
        • Hassanein K.
        Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity.
        Altern Ther Health Med. 2000; 6: 68-80
        • Reeves K.D.
        • Hassanein K.
        Randomized, prospective placebo-controlled double blind study of dextrose prolotherapy for osteoarthritic thumbs and finger (DIP, PIP, and trapeziometacarpal) joints.
        J Altern Complement Med. 2000; 6: 311-320
        • Reeves K.D.
        • Hassanein K.
        Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity.
        Altern Ther Health Med. 2003; 9: 58-62
        • Reeves K.D.
        Prolotherapy.
        in: Lennard T.A. Pain procedures in clinical practice. 2nd ed. Hanley & Belfus, Philadelphia2000: 172-190
        • O’Conner F.G.
        • Howard T.M.
        • Fieseler C.M.
        • Nirschl R.P.
        Managing overuse injuries.
        Physician Sportsmedicine. 1997; 25: 88-113
        • LeBlanc K.E.
        • LeBlanc K.A.
        Groin pain in athletes.
        Hernia. 2003; 7: 68-71
        • Fricker P.A.
        • Taunton J.E.
        • Ammann W.
        Osteitis pubis in athletes. Infection, inflammatory, or injury?.
        Sports Med. 1991; 12: 266-279
        • Combs J.A.
        Bacterial osteitis pubis in a weight lifter without invasive trauma.
        Med Sci Sport Exerc. 1998; 30: 1561-1563
        • Holt M.A.
        • Keene J.S.
        • Graf B.K.
        • Helwig D.C.
        Treatment of osteitis pubis in athletes.
        Am J Sports Med. 1995; 23: 601-606
        • Mulhall K.J.
        • McKenna J.
        • Walsh A.
        • McCormack D.
        Osteitis pubis in professional soccer players.
        Clin J Sports Med. 2002; 12: 179-181
        • Taylor M.A.
        • Norman T.L.
        • Clovis N.B.
        • Blaha J.D.
        The response of rabbit patellar tendons after autologous blood injection.
        Med Sci Sports Exerc. 2002; 34: 70-73
        • Yelland M.J.
        • Glasziou P.P.
        • Bogduk N.
        • Schluter P.J.
        • McKernon M.
        Prolotherapy injections, saline injections, and exercise for chronic low back pain.
        Spine. 2004; 29: 9-16
        • Altay T.
        • Gunal I.
        • Ozturk H.
        Local injection treatment for lateral epicondylitis.
        Clin Orthop. 2002; (May(398)): 127-130
        • Chun J.
        • Tuan T.L.
        • Han B.
        • Vangsness C.T.
        • Nimni M.E.
        Cultures of ligament fibroblasts in fibrin matrix gel.
        Connect Tissue Res. 2003; 44: 81-87