We thank Rabadi et al for their letter regarding our article
1
on the association between serum apolipoprotein E4 (APOE∗E4) and rehabilitation outcome of hospitalized ischemic stroke patients where, notwithstanding
lack of relationship with functional outcome, an increased prevalence of patients
with aphasia was noted. Their observation of the low prevalence of the apo E4 lipoprotein
in a population of nonaphasic ischemic stroke patients lends further support to the
potential value of the APOE∗E4 allele as a biologic marker in poststroke aphasic patients. The incidence of APOE∗E4 allele in their sample, being even lower than in the general population, clearly
indicates the possible influence of other factors that may be linked to a subject’s
race or genetic determinism that are related to the presence of the APOE∗E4 allele and, at the same time, highlights the high prevalence of APOE∗E4 found in our own sample of patients with aphasia. We limited statistical analysis
in our study to subgroups of patients after stroke with or without neglect (right
hemisphere damage) or with or without aphasia (left hemisphere damage).To read this article in full you will need to make a payment
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References
- Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.Arch Phys Med Rehabil. 2003; 84: 973-976
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© 2004 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.