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Deparment| Volume 85, ISSUE 3, P517-518, March 2004

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      We thank Rabadi et al for their letter regarding our article
      • Treger I.
      • Froom P.
      • Ring H.
      • Friedman G.
      Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.
      on the association between serum apolipoprotein E4 (APOE∗E4) and rehabilitation outcome of hospitalized ischemic stroke patients where, notwithstanding lack of relationship with functional outcome, an increased prevalence of patients with aphasia was noted. Their observation of the low prevalence of the apo E4 lipoprotein in a population of nonaphasic ischemic stroke patients lends further support to the potential value of the APOE∗E4 allele as a biologic marker in poststroke aphasic patients. The incidence of APOE∗E4 allele in their sample, being even lower than in the general population, clearly indicates the possible influence of other factors that may be linked to a subject’s race or genetic determinism that are related to the presence of the APOE∗E4 allele and, at the same time, highlights the high prevalence of APOE∗E4 found in our own sample of patients with aphasia. We limited statistical analysis in our study to subgroups of patients after stroke with or without neglect (right hemisphere damage) or with or without aphasia (left hemisphere damage).
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      References

        • Treger I.
        • Froom P.
        • Ring H.
        • Friedman G.
        Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.
        Arch Phys Med Rehabil. 2003; 84: 973-976