The article by Treger et al
1
is a welcome addition to the literature on the influence of apolipoprotein E4 (APOE∗E4) on functional recovery in ischemic stroke rehabilitation. Similar to other investigations,
2
,
3
Treger’s study showed that the APOE genotype did not influence the injury severity or functional recovery after ischemic
stroke. However, Treger
1
noted an incidental finding of an increased prevalence of aphasia in subjects with
APOE∗E4 that nearly reached statistical significance. Lacking a feasible neurobiologic hypothesis
for this finding, the question we ask is whether the presence of aphasia was an indirect
clinical marker of overall cognitive impairment among these subjects and whether APOE status had an effect on cognitive function.To read this article in full you will need to make a payment
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References
- Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.Arch Phys Med Rehabil. 2003; 84: 973-976
- The apolipoprotein E epsilon4 allele and outcome in cerebrovascular disease.Stroke. 1998; 29: 1882-1887
- Prospective study of apolipoprotein E genotype and functional outcome following ischemic stroke.Arch Neurol. 2000; 57: 1480-1484
Article info
Identification
Copyright
© 2004 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
