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Effect of ultrasound on acute inflammation of transected medial collateral ligaments1

      Abstract

      Leung MC, Ng GY, Yip KK. Effect of ultrasound on acute inflammation of transected medial collateral ligaments. Arch Phys Med Rehabil 2004;85:963–6.

      Objective

      To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).

      Design

      Randomized, case-control study.

      Setting

      Laboratory animal facility.

      Animals

      Thirty 3-month-old male Sprague-Dawley rats.

      Intervention

      Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm2).

      Main outcome measures

      Levels of PGE2 and LTB4.

      Results

      The levels of PGE2 and LTB4 were higher in all intensity subgroups that received 2.3W/cm2 intensity on postinjury day 2. On postinjury day 11, LTB4 was significantly decreased, but PGE2 was significantly increased.

      Conclusions

      Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.

      Keywords

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