Effect of ultrasound on acute inflammation of transected medial collateral ligaments1


      Leung MC, Ng GY, Yip KK. Effect of ultrasound on acute inflammation of transected medial collateral ligaments. Arch Phys Med Rehabil 2004;85:963–6.


      To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).


      Randomized, case-control study.


      Laboratory animal facility.


      Thirty 3-month-old male Sprague-Dawley rats.


      Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm2).

      Main outcome measures

      Levels of PGE2 and LTB4.


      The levels of PGE2 and LTB4 were higher in all intensity subgroups that received 2.3W/cm2 intensity on postinjury day 2. On postinjury day 11, LTB4 was significantly decreased, but PGE2 was significantly increased.


      Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Archives of Physical Medicine and Rehabilitation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Wood R.W
        • Loomis A.L
        The physical and biological effects of high-frequency sound waves of great intensity.
        London Edinburgh Dublin Philos Magazine J Sci. 1927; 4: 417-436
        • ter Haar G
        Therapeutic ultrasound.
        Eur J Ultrasound. 1999; 9: 3-9
        • Low J
        • Reed A
        Electrotherapy explained. Principles and practice. 2nd ed. Butterworth Heinemann, Singapore1994
        • ter Haar G
        Basic physics of therapeutic ultrasound.
        Physiotherapy. 1978; 64: 100-103
        • Young S
        Ultrasound therapy.
        in: Kitchen S Bazin S Clayton’s electrotherapy. WB Saunders, Tokyo1996: 243-267
        • ter Haar G
        • Dyson M
        • Oakley E.M
        The use of ultrasound by physiotherapists in Britain.
        Ultrasound Med Biol. 1985; 13: 659-663
        • Baker K.G
        • Robertson V.J
        • Duck F.A
        A review of therapeutic ultrasound.
        Phys Ther. 2001; 81: 1351-1358
        • Kahn J
        Principles and practice of electrotherapy. 3rd ed. Churchill Livingstone, Tokyo1994
        • Robertson V.J
        • Baker K.G
        A review of therapeutic ultrasound.
        Phys Ther. 2001; 81: 1339-1350
        • Goddard D.H
        • Revell P.A
        • Cason J
        • Gallagher S
        • Currey H.L
        Ultrasound has no anti-inflammatory effect.
        Ann Rheum Dis. 1983; 42: 582-584
        • Binder A
        • Hodge G
        • Greenwood A.M
        • Hazleman B.L
        • Page Thomas D.P
        Is therapeutic ultrasound effective in treating soft tissue lesions?.
        BMJ (Clin Res Ed). 1985; 290: 512-514
        • Hashish I
        • Harvey W
        • Harris M
        Anti-inflammatory effects of ultrasound therapy.
        Br J Rheumatol. 1986; 25: 77-81
        • Snow C.J
        • Johnson K.A
        Effect of therapeutic ultrasound on acute inflammation.
        Physiother Can. 1988; 40: 162-167
        • Davies P
        • MacIntyre D.E
        Prostaglandins and inflammation.
        in: Gallin J.I Goldstein I.M Snyderman R Inflammation basic principles and clinical correlates. Raven Pr, New York1992: 123-138
        • Williams T.J
        • Peck M.J
        Role of prostaglandin-mediated vasodilation in inflammation.
        Nature. 1977; 270: 530-532
        • White D.M
        Mechanism of prostaglandin E2-induced substance P release from cultured sensory neurons.
        Neuroscience. 1996; 70: 561-565
        • Palmer R.M
        • Stepney R.J
        • Higgs G.A
        • Eakins K.E
        Chemokinetic activities of arachidonic and ipoxygenase products on leukocytes of different species.
        Prostaglandins. 1980; 20: 411-418
        • Sha’afi R.I
        • Naccache P.H
        • Molski T.F
        • Borgeat P
        • Goetzl E.J
        Cellular regulatory role of leukotriene B4.
        J Cell Physiol. 1981; 108: 401-408
        • Hoover R.L
        • Karnovsky M.J
        • Austen K.F
        • Corey E.J
        • Lewis R.A
        Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion.
        Proc Natl Acad Sci U S A. 1984; 81: 2191-2193
        • Brach M.A
        • de Vos S
        • Arnold C
        • Gruss H.J
        • Mertelsmann R
        • Herrmann F
        Leukotriene B4 transcriptionally activates interleukin-6 expression involving NF-kB and NF-IL6.
        Eur J Immunol. 1992; 22: 2705-2711
        • Li J.G
        • Chang W.H
        • Lin J.C
        • Sun J.S
        Optimum intensities of ultrasound for PGE2 secretion and growth of osteoblasts.
        Ultrasound Med Biol. 2002; 28: 683-690
        • De Deyne P.G
        • Kirsch-Volders M
        In vitro effects of therapeutic ultrasound on the nucleus of human fibroblasts.
        Phys Ther. 1995; 75: 629-634
        • Yoshino S
        Patterns of prostaglandin E2 and leukotriene B4 production in inflammation induced by peptidoglycan-polysaccharide polymers of bacterial cell walls.
        Comp Immunol Microbiol Infect Dis. 1995; 18: 137-144