Abstract
Leung MC, Ng GY, Yip KK. Effect of ultrasound on acute inflammation of transected
medial collateral ligaments. Arch Phys Med Rehabil 2004;85:963–6.
Objective
To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue
injuries by measuring the levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).
Design
Randomized, case-control study.
Setting
Laboratory animal facility.
Animals
Thirty 3-month-old male Sprague-Dawley rats.
Intervention
Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound
therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5,
1.5, 2.3W/cm2).
Main outcome measures
Levels of PGE2 and LTB4.
Results
The levels of PGE2 and LTB4 were higher in all intensity subgroups that received 2.3W/cm2 intensity on postinjury day 2. On postinjury day 11, LTB4 was significantly decreased, but PGE2 was significantly increased.
Conclusions
Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.
Keywords
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Article Info
Footnotes
☆Supported by Faculty Area of Strategic Development, Department of Rehabilitation Sciences, Hong Kong Polytechnic University (grant no. A106).
Identification
Copyright
© 2004 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
