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The effect of spasticity on cortical somatosensory-evoked potentials: Changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection

  • Eun Sook Park
    Affiliations
    Rehabilitation Department, Yonsei University College of Medicine (ES Park, CI Park, DY Kim); Cerebral Palsy and the Pediatric Section (ES Park), Research Institute of Rehabilitation Medicine (CI Park); Brain Korea 21 Project for Medical Science, Yonsei University (ES Park); and Rehabilitation Department, Severance Hospital (YR Kim), Seoul, Korea
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  • Chang Il Park
    Affiliations
    Rehabilitation Department, Yonsei University College of Medicine (ES Park, CI Park, DY Kim); Cerebral Palsy and the Pediatric Section (ES Park), Research Institute of Rehabilitation Medicine (CI Park); Brain Korea 21 Project for Medical Science, Yonsei University (ES Park); and Rehabilitation Department, Severance Hospital (YR Kim), Seoul, Korea
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  • Deog Young Kim
    Affiliations
    Rehabilitation Department, Yonsei University College of Medicine (ES Park, CI Park, DY Kim); Cerebral Palsy and the Pediatric Section (ES Park), Research Institute of Rehabilitation Medicine (CI Park); Brain Korea 21 Project for Medical Science, Yonsei University (ES Park); and Rehabilitation Department, Severance Hospital (YR Kim), Seoul, Korea
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  • Yong Rae Kim
    Affiliations
    Rehabilitation Department, Yonsei University College of Medicine (ES Park, CI Park, DY Kim); Cerebral Palsy and the Pediatric Section (ES Park), Research Institute of Rehabilitation Medicine (CI Park); Brain Korea 21 Project for Medical Science, Yonsei University (ES Park); and Rehabilitation Department, Severance Hospital (YR Kim), Seoul, Korea
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      Abstract

      Park ES, Park CI, Kim DY, Kim YR. The effect of spasticity on cortical somatosensory-evoked potentials: changes of cortical somatosensory-evoked potentials after botulinum toxin type A injection. Arch Phys Med Rehabil 2002:83:1592-6. Objective: To evaluate the changes in cortical somatosensory-evoked potentials (SEPs) after botulinum toxin type A injection to determine what effect spasticity has on cortical SEPs. Design: Intervention study and before-after trial. Setting: University-affiliated hospital in Korea. Participants: Twelve children with spastic hemiplegic cerebral palsy (CP), 7 children with spastic diplegic CP, and 8 patients with traumatic brain injury. Intervention: All participants had botulinum toxin type A injected into the muscles of the spastic limb. Main Outcome Measures: SEPs were recorded before and 7 days after the botulinum toxin type A injection. Spasticity of the affected spastic limb was also measured. The short latency and amplitude of waves in SEPs were measured. The SEP results were divided into 3 groups: flat (no evoked potential), abnormal (evoked but delayed in latency), and normal (clear waveform with normal latency). Results: The normal response of cortical SEP increased after injection. The SEPs exhibited more frequent improvement in the limbs, with greater improvement of spasticity in grade (>1.0 grade) and in patients of younger age (<3y) after injection (P<.05). Conclusion: The observed improvement of cortical SEPs with associated reduction of spasticity that occurred after the botulinum toxin type A injection indicates that spasticity itself can be considered a factor affecting cortical SEPs. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation

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