Abstract
Penrod LE, Allen JB, Cabacungan LR. Warfarin resistance and enteral feedings: 2 case
reports and a supporting in vitro study. Arch Phys Med Rehabil 2001;82:1270-3. This
study investigated whether an interaction between common enteral feeding products
and warfarin exists. Two clinical cases of apparent interaction spurred a supporting
in vitro study. Both the clinical cases and the in vitro study showed that several
enteral feeding products bind warfarin, reducing the bioavailability of the drug.
The binding appears to occur between warfarin and the protein component of the feeding
product. This clinically important interaction is likely when warfarin and enteral
feeding products are used concurrently. Clinicians should be aware of this potential
interaction and monitor the therapy closely, particularly when enteral feeding is
discontinued. © 2001 by the American Congress of Rehabilitation Medicine and the American Academy
of Physical Medicine and Rehabilitation
Keywords
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Article info
Publication history
Accepted:
August 7,
2000
Footnotes
☆Supported in part by an internal educational grant from the University of Alabama.
☆☆No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.
★Reprint requests to Louis E. Penrod, MD, Dept of Physical Medicine and Rehabilitation, Ste 901, Kaufmann Bldg, 3471 Fifth Ave, Pittsburgh, PA 15213, e-mail: [email protected]
★★Suppliers
♢a. Ross Products Div, Abbott Laboratories Inc, 625 Cleveland Ave, Columbus, OH 43125.
♢♢b. Mead Johnson Nutritionals, 2400 W Lloyd Expwy, Evansville, IN 47721.
Identification
Copyright
© 2001 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
