Abstract
Simão AP, Avelar NC, Tossige-Gomes R, Neves CD, Mendonça VA, Miranda AS, Teixeira
MM, Teixeira AL, Andrade AP, Coimbra CC, Lacerda AC. Functional performance and inflammatory
cytokines after squat exercises and whole-body vibration in elderly individuals with
knee osteoarthritis.
Objective
To investigate the effects of squat exercises combined with whole-body vibration on
the plasma concentration of inflammatory markers and the functional performance of
elderly individuals with knee osteoarthritis (OA).
Design
Clinical, prospective, randomized, single-blinded study.
Setting
Exercise physiology laboratory.
Participants
Elderly subjects with knee OA (N=32) were divided into 3 groups: (1) squat exercises
on a vibratory platform (platform group, n=11); (2) squat exercises without vibration
(squat group, n=10); and (3) the control group (n=11).
Interventions
The structured program of squat exercises in the platform and squat groups was conducted
3 times per week, on alternate days, for 12 weeks.
Main Outcome Measures
Plasma soluble tumor necrosis factor-α receptors 1 (sTNFR1) and 2 (sTNFR2) were measured
using immunoassays (the enzyme-linked immunosorbent assay method). The Western Ontario
and McMaster Universities Osteoarthritis Index questionnaire was used to evaluate
self-reported physical function, pain, and stiffness. The 6-minute walk test, the
Berg Balance Scale, and gait speed were used to evaluate physical function.
Results
In the platform group, there were significant reductions in the plasma concentrations
of the inflammatory markers sTNFR1 and sTNFR2 (P<.001 and P<.05, respectively) and self-reported pain (P<.05) compared with the control group, and there was an increase in balance (P<.05) and speed and distance walked (P<.05 and P<.001, respectively). In addition, the platform group walked faster than the squat
group (P<.01).
Conclusions
The results suggest that whole-body vibration training improves self-perception of
pain, balance, gait quality, and inflammatory markers in elderly subjects with knee
OA.
Key Words
List of Abbreviations:
BMI (body mass index), g (gravity), IL (interleukin), OA (osteoarthritis), sTNFR1 (soluble tumor necrosis factor-α receptor-1), sTNFR2 (soluble tumor necrosis factor-α receptor-2), sTNFRs (soluble receptors of tumor necrosis factor-α), TNF-α (tumor necrosis factor-α), TNFR1 (cell surface tumor necrosis factor-α receptor-1), TNFR2 (cell surface tumor necrosis factor-α receptor-2), WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: April 30, 2012
Footnotes
Supported by FAPEMIG, CNPq, and CAPES.
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
Clinical Trial Registration No.: ACTRN12610000475044.
In-press corrected proof published online on Jun 15, 2012, at www.archives-pmr.org.
Identification
Copyright
© 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
