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Exercise Significantly Increases Plasma Adrenaline and Oxidized Low-Density Lipoprotein in Normal Healthy Subjects But Not in Persons With Spinal Cord Injury

Published:February 13, 2012DOI:https://doi.org/10.1016/j.apmr.2011.08.046

      Abstract

      Mitsui T, Nakamura T, Ito T, Umemoto Y, Sakamoto K, Kinoshita T, Nakagawa M, Tajima F. Exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein in normal healthy subjects but not in persons with spinal cord injury.

      Objectives

      To compare plasma concentrations of oxidized low-density lipoprotein (oxLDL) and adrenaline during exercise between persons with spinal cord injury (SCI) and able-bodied (AB) individuals.

      Design

      Randomized controlled study.

      Setting

      Human laboratory at a medical university.

      Participants

      Persons with SCI (n=7) and AB individuals (n=9).

      Intervention

      Two-hour arm crank ergometer exercise at 60% maximum oxygen consumption.

      Main Outcome Measures

      Plasma oxLDL and adrenaline levels.

      Results

      Exercise significantly increased plasma adrenaline levels in AB persons (mean ± SD: rest, 45.4±32.2pg/mL; exercise, 200.9±113.7pg/mL; P<.05) and persons with SCI; however; the magnitude of the increase in those with SCI was attenuated (mean ± SD: rest, 45.4±14.0pg/mL; exercise, 83.0±55.8pg/mL; P<.05). Exercise also significantly increased plasma oxLDL levels in AB persons (mean ± SD: rest, 102.2±30.2U/L; exercise, 179.7±60.0U/L; P<.05), but not in persons with SCI (mean ± SD: rest, 124.3±66.0U/L; exercise, 138.9±59.5U/L).

      Conclusions

      The results suggest that increases in plasma adrenaline levels during exercise contribute to the increase in plasma oxLDL levels.

      Key Words

      List of Abbreviations:

      AB (able-bodied), oxLDL (oxidized low-density lipoprotein), SCI (spinal cord injury), V̇o2max (maximum oxygen consumption)
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