Article| Volume 74, ISSUE 5, P463-467, May 1993

Hydrocortisone and exercise effects on articular cartilage in rats

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      The combined effects of hydrocortisone and running exercise on articular cartilage were assessed in female Sprague-Dawley rats. Animals were divided into three groups: 12 control (C), 12 who received an injection of 0.1mL hydrocortisone once a week for three weeks (HC), and 12 rats who received three weekly injections of hydrocortisone and ran twice daily for six weeks (HC + run). Previous study revealed that rats that ran on a treadmill for three to 12 months did not have articular cartilage that was different from controls and thus a fourth group of rats, runners only, was not included in this analysis. At sacrifice, both knees were examined, photographed, and subsequently decalcified, then sectioned at 6μ and stained. HC + run rats had significantly more surface degeneration on femoral cartilage than HC or C rats. Eight of 12 HC + run rats displayed fibrotic invasion and/or subchondral bone replacement of degenerated articular cartilage, a feature not seen in HC or C rats. Cross-sections from HC + run rats displayed areas of cell death, and loss of matrix staining. Results suggest that, in rats, running exercise combined with intraarticular injections of hydrocortisone is more detrimental to articular cartilage than hydrocortisone or running alone.


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        • Holden G
        • Kendall PH
        The newer corticosteroids for local injection.
        Ann Phys Med. 1962; 6: 178-182
        • Murdoch WR
        • Will G
        Methyl prednisolone acetate in intra-articular therapy.
        Br Med J. 1962; 1: 604-606
        • Steinberg CLR
        • Duthie RD
        • Piva AE
        Charcoat-like arthropathy following inta-articular hydrocortisone.
        JAMA. 1962; 181: 851-854
        • Hollander JL
        • Brown EM
        • Jessar RA
        • Brown CY
        Hydrocortisone and cortisone injected into arthritic joints. comparative effects of and use of hydrocortisone as a local arthritic agent.
        JAMA. 1951; 147: 1629-1635
        • Bentley G
        Papain-induced degenerative arthritis of the hip in rabbits.
        J Bone Joint Surg. 1971; 53B: 324-337
        • Bentley G
        • Goodfellow JW
        Disorganization of the knee following intra-articular hydrocortisone injections.
        J Bone Joint Surg. 1969; 51B: 498-504
        • Chandler GN
        • Wright V
        Deleterious effect of intra-articular hydrocortisone.
        Lancet. 1958; 2: 661-663
        • Chandler GN
        • Wright V
        • Hartfall SJ
        Intra-articular therapy in rheumatoid arthritis. comparison of hydrocortisone tertiary butyl acetate and hydrocortisone acetate.
        Lancet. 1958; 2: 659-661
        • Sweetnam DR
        • Mason RM
        • Murray RO
        Steroid arthropathy of the hip.
        Br Med J. 1960; 1: 1392-1394
        • Behrens F
        • Shepard N
        • Mitchell N
        Alteration of rabbit articular cartilage of intra-articular injections of glucocorticoids.
        J Bone Joint Surg. 1975; 57A: 70-76
        • Ekholm R
        • Norback B
        On the relationship between articular changes and function.
        Acta Orthop Scan. 1951; 21: 81-98
        • Lanier RR
        Effects of exercise on the knee joints of inbred mice.
        Anat Rec. 1946; 94: 311-319
        • Saaf J
        Effect of exercise on articular cartilage.
        Acta Orthop Scand. 1950; 20: 1-83
        • Meachim G
        Light microscopy of India ink preparations of fibrillated cartilage.
        Ann Rheum Dis. 1972; 31: 457-464
        • Miller WT
        • Restifo RA
        Steroid arthropathy.
        Radiology. 1966; 86: 652-657
        • Enneking WF
        • Horowitz M
        The intra-articular effects of immobilization on the human knee.
        J Bone Joint Surg. 1972; 54A: 973-985
        • Sood SC
        A study of the effects of experimental immobilization on rabbit articular cartilage.
        J Anat. 1971; 108: 497-507
        • Salter RB
        • Simmons DF
        • Malcolm BW
        • et al.
        The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage.
        J Bone Joint Surg. 1980; 62A: 1232-1251
        • Kopta JA
        • Blosser JA
        Elasticity of articular cartilage: effects of intra-articular administration and medial menisectomy.
        Clin Orthop. 1969; 64: 21-32
        • Ishikawa K
        • Ohira T
        • Sakata H
        Effects of intra-articular injections of halopredone diacetate on the articular cartilage of rat knees: a comparison with methylprednisolone acetate.
        Toxicol Appl Pharmacol. 1984; 75: 423-436