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Abstract
The combined effects of hydrocortisone and running exercise on articular cartilage
were assessed in female Sprague-Dawley rats. Animals were divided into three groups:
12 control (C), 12 who received an injection of 0.1mL hydrocortisone once a week for
three weeks (HC), and 12 rats who received three weekly injections of hydrocortisone
and ran twice daily for six weeks (HC + run). Previous study revealed that rats that
ran on a treadmill for three to 12 months did not have articular cartilage that was
different from controls and thus a fourth group of rats, runners only, was not included
in this analysis. At sacrifice, both knees were examined, photographed, and subsequently
decalcified, then sectioned at 6μ and stained. HC + run rats had significantly more
surface degeneration on femoral cartilage than HC or C rats. Eight of 12 HC + run
rats displayed fibrotic invasion and/or subchondral bone replacement of degenerated
articular cartilage, a feature not seen in HC or C rats. Cross-sections from HC +
run rats displayed areas of cell death, and loss of matrix staining. Results suggest
that, in rats, running exercise combined with intraarticular injections of hydrocortisone
is more detrimental to articular cartilage than hydrocortisone or running alone.
Keywords
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Article info
Publication history
Accepted:
April 24,
1992
Received:
November 11,
1991
Identification
Copyright
© 1993 Published by Elsevier Inc.
