Archives of Physical Medicine and Rehabilitation
Volume 80, Issue 5 , Pages 545-550, May 1999

Functional magnetic stimulation: A new modality for enhancing systemic fibrinolysis☆

  • Vernon W.H. Lin, MD, PhD

      Affiliations

    • Corresponding Author InformationReprint requests to Vernon W.H. Lin, MD, PhD, Spinal Cord Injury Service (128), VA Long Beach, 5901 E 7th Street, Long Beach, CA 90822.
    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA
    • ,
  • Arundhati Perkash, MD, PhD

      Affiliations

    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA
    • ,
  • Hongjian Liu, MD

      Affiliations

    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA
    • ,
  • Danielle Todd, BSc

      Affiliations

    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA
    • ,
  • Ian Hsiao, PhD

      Affiliations

    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA
    • ,
  • Inder Perkash, MD

      Affiliations

    • Spinal Cord Injury Service, VA Palo Alto Health Care System, Palo Alto, USA
    • Division of Physical Medicine and Rehabilitation, Department of Functional Restoration, Stanford University School of Medicine, Stanford, CA, USA

Received 17 August 1998; accepted 12 November 1998.

Abstract 

Objective: To investigate whether functional magnetic stimulation (FMS) of the leg muscles could enhance systemic fibrinolysis.

Design: A within-subject analysis of systemic fibrinolysis before and after 60 minutes of FMS.

Setting: The Functional Magnetic Stimulation and Special Coagulation Laboratories in the Spinal Cord Injury Service at a Veterans Administration health care facility.

Participants: Twenty healthy volunteers were recruited. The exclusion criteria were: (1) personal or family history of venous or arterial thrombosis, (2) personal or family history of cardiac arrythmias, (3) current use of medication, and (4) the presence of a cardiac pacemaker or other metallic implants.

Main Outcome Measures: Whole blood clot lysis time (WBCLT) and tissue plasminogen activator (t-PA) antigen determined at baseline and 10 and 60 minutes after FMS.

Results: A significant decrease was observed in the mean WBCLT after FMS. The WBCLT decreased from 17 ± 1.3h before FMS to 12 ± 1.0h and 11 ± 0.8h at 10 and 60 minutes post-FMS, respectively. The mean t-PA antigen levels did not show a significant change (p = .6701) from pre-FMS (6.7 ± 0.91ng/mL) to 10min post-FMS (6.8 ± 0.91ng/mL) and 60min post-FMS (7.0 ± 1.02ng/mL). Several patterns of fibrinolytic response to FMS were observed. They differed in relation to the degree of enhancement, the period at which maximum enhancement occurred, and the corresponding t-PA antigen levels observed.

Conclusions: The FMS-induced contractions of the leg muscles enhanced systemic fibrinolysis ex vivo. The improvement in fibrinolysis occurred immediately after FMS and was also observed at 60 minutes post-FMS. FMS appears to produce a sustained enhancement of systemic fibrinolysis that may prove useful in deep-vein thrombosis prophylaxis.

No full text is available. To read the body of this article, please view the PDF online.

 

☆ No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

PII: S0003-9993(99)90197-1

Archives of Physical Medicine and Rehabilitation
Volume 80, Issue 5 , Pages 545-550, May 1999

Article Tools