Archives of Physical Medicine and Rehabilitation
Volume 91, Issue 9 , Pages 1332-1338 , September 2010

Preparation for Compensatory Forward Stepping in Parkinson's Disease

Presented to the International Society for Posture and Gait, June 21–25, 2009, Bologna, Italy.

  • Laurie A. King, PhD, PT

      Affiliations

    • Department of Neurology, Oregon Health and Science University, Beaverton, OR
    • Corresponding Author InformationReprint requests to Laurie King, PhD, 505 NW 185th Ave, Beaverton, OR 97006
    • ,
  • Rebecca J. St George, PhD

      Affiliations

    • Department of Neurology, Oregon Health and Science University, Beaverton, OR
    • ,
  • Patricia Carlson-Kuhta, PhD

      Affiliations

    • Department of Neurology, Oregon Health and Science University, Beaverton, OR
    • ,
  • John G. Nutt, MD

      Affiliations

    • Department of Neurology, Oregon Health and Science University, Beaverton, OR
    • ,
  • Fay B. Horak, PhD, PT

      Affiliations

    • Department of Neurology, Oregon Health and Science University, Beaverton, OR
    • Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, OR
    • Department of Physiology and Pharmacology, Oregon Health and Science University, Beaverton, OR

References 

  1. Pickering RM, Grimbergen YA, Rigney U, et al. A meta-analysis of six prospective studies of falling in Parkinson's disease. Mov Disord. 2007;22:1892–1900
  2. Horak FB, Frank J, Nutt J. Effects of dopamine on postural control in parkinsonian subjects: scaling, set, and tone. J Neurophysiol. 1996;75:2380–2396
  3. Horak FB, Dimitrova D, Nutt JG. Direction-specific postural instability in subjects with Parkinson's disease. Exp Neurol. 2005;193:504–521
  4. Bloem BR, Valkenburg VV, Slabbekoorn M, Willemsen MD, van Vugt J, Beckley DJ. Postural instability and falls in Parkinson's disease. Adv Neurol. 2001;87:209–223
  5. Horak FB, MacPherson JM. Postural orientation and equilibrium. In:  Smith JL editors. Handbook of physiology; section 12—exercise: regulation and integration of multiple systems. New York: Oxford Univ Pr; 1996;p. 255–292
  6. Maki BE, McIlroy WE. Postural control in the older adult. Clin Geriatr Med. 1996;12:635–658
  7. Winter DA, Ruder GK, MacKinnon CD. Control of balance of upper body during gait. In:  Winters JM,  Woo SL-Y editor. Multiple muscle systems: biomechanics and movements organization. Springer-Verlag; 1990;p. 534–535
  8. MacPherson JM, Horak F. Neural control of posture. In: Kandel E, Schwartz J, Jessell T, editors. Principles of neural science. 5th ed. New York: Elsevier.
  9. McIlroy WE, Maki BE. Do anticipatory postural adjustments precede compensatory stepping reactions evoked by perturbation?. Neurosci Lett. 1993;164:199–202
  10. Burleigh-Jacobs A, Horak FB, Nutt JG, Obeso JA. Step initiation in Parkinson's disease: influence of levodopa and external sensory triggers. Mov Disord. 1997;12:206–215
  11. Mancini M, Zampieri C, Carlson-Kuhta P, Chiari L, Horak FB. Anticipatory postural adjustments prior to step initiation are hypometric in untreated Parkinson's disease: an accelerometer-based approach. Eur J Neurol. 2009;16:1028–1034
  12. King LA, Horak FB. Lateral stepping for postural correction in Parkinson's disease. Arch Phys Med Rehabil. 2008;89:492–499
  13. Jacobs JV, Nutt JG, Carlson-Kuhta P, Stephens M, Horak FB. Knee trembling during freezing of gait represents multiple anticipatory postural adjustments. Exp Neurol. 2009;215:334–341
  14. Fahn S, Elton R. Unified Parkinson's disease rating scale. In:  Fahn S,  Marsden D,  Calne D editor. Recent developments in parkinson diseases. London: Macmillan; 1987;p. 153–163
  15. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967;17:427–442
  16. McIlroy WE, Maki BE. The control of lateral stability during rapid stepping reactions evoked by antero-posterior perturbation: does anticipatory control play a role?. Gait Posture. 1999;9:190–198
  17. Henry S, Fung J, Horak FB. Control of stance during lateral and anterior/ posterior surface translations. IEEE Trans Rehabil Eng. 1998;6:32–42
  18. Bronte-Stewart HM, Minn AY, Rodrigues K, Buckley EL, Nashner LM. Postural instability in idepoathic Parkinson's disease: the role of medication and unilateral pallidotomy. Brain. 2002;125:2100–2114
  19. Purdue MJ. The basal ganglia and posture. London: Pitman Medical Publishing Co, Ltd; 1967;
  20. Burleigh A, Horak FB, Nutt JG, Obeso JA. Step initiation in Parkinson's disease: influence of levodopa and external sensory triggers. Mov Disord. 1997;12:206–215
  21. Rocchi L, Chiari L, Mancini M, Carlson-Kuhta P, Gross A, Horak FB. Step initiation in Parkinson's disease: influence of initial stance conditions. Neurosci Lett. 2006;406:128–132
  22. Hallett M. The intrinsic and extrinsic aspects of freezing of gait. Mov Disord. 2008;23(Suppl 2):S439–S443
  23. Frank JS, H F, Nutt J. Centrally initiated postural adjustments in parkinsonian patients on and off levodopa. J Neurophysiol. 2000;84:2240–2248
  24. Maki BE, Edmondstone MA, Perry SD, Heung E, Quant S, McIlroy WE. Control of rapid limb movements for balance recovery: do age-related changes predict falling risk?. In:  Duysens J,  S-E B,  Kingma H editor. Control of posture and gait. Maastricht: International Society for Postural and Gait Research; 2001;p. 126–129
  25. Protas EJ, Mitchell K, Williams A, Qureshy H, Caroline K, Lai EC. Gait and step training to reduce falls in Parkinson's disease. NeuroRehabilitation. 2005;20:183–190
  26. Rogers MW, Johnson ME, Martinez KM, Mille ML, Hedman LD. Step training improves the speed of voluntary step initiation in aging. J Gerontol A Biol Sci Med Sci. 2003;58A:46–51
  27. Hall LM, Brauer S, Horak FB, Hodges PW. Adaptive changes in anticipatory postural adjustments with novel and familiar postural supports. J Neurophysiol. 2009;103:968–976

 Supported by the National Institutes of Health (grant nos. AG019706 and AG006457) and the Parkinson's Alliance.

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.

PII: S0003-9993(10)00305-9

doi: 10.1016/j.apmr.2010.05.013

Archives of Physical Medicine and Rehabilitation
Volume 91, Issue 9 , Pages 1332-1338 , September 2010

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