Preparation for Compensatory Forward Stepping in Parkinson's Disease

Abstract 

King LA, St George RJ, Carlson-Kuhta P, Nutt JG, Horak FB. Preparation for compensatory forward stepping in Parkinson's disease.

Objective

To characterize preparation for compensatory stepping in people with Parkinson's disease (PD) compared with healthy control subjects, and to determine whether levodopa medication improves preparation or the execution phases of the step.

Design

Observational study.

Setting

Outpatient neuroscience laboratory.

Participants

Nineteen participants with idiopathic PD tested both in the on and off levodopa states and 17 healthy subjects.

Intervention

Moveable platform with posterior translations of 24cm at 56cm/s.

Main Outcome Measures

Compensatory steps forward, in response to a backward surface translation (24cm amplitude at 56cm/s), were categorized according to the presence of an anticipatory postural adjustment (APA) before stepping: no APA, single APA, or multiple APAs. The following step parameters were calculated: step latency, step length, center of mass (CoM) average velocity, and CoM displacement at the step initiation.

Results

Lateral APAs were evident in 57% and 42% of trials for people with PD in the off and on medication states, respectively, compared with only 10% of trials for control subjects. Compared with subjects with PD who did not have APAs, those subjects with PD who did make an APA prior to stepping had significantly later (mean ± SEM, 356±16ms vs 305±8ms) and shorter (mean ± SEM, 251±27mm vs 300±16mm) steps, their CoM was significantly farther forward (185±7mm vs 171±5mm) at foot-off, and they took significantly more steps to regain equilibrium. Levodopa did not affect the preparation or execution phase of compensatory stepping. Poor axial scores and reports of freezing in the United Parkinson's Disease Rating Scale were associated with use of 1 or more APAs before compensatory stepping.

Conclusions

Lateral postural preparation prior to compensatory stepping in subjects with PD was associated with inefficient balance recovery from external perturbations.

Key Words: Parkinson disease, Rehabilitation

List of Abbreviations: APA, anticipatory postural adjustment, CoM, center of mass, CoP, center of pressure, PD, Parkinson's disease, PIGD, Postural Instability and Gait Disorder Score, UPDRS, United Parkinson's Disease Rating Scale