Archives of Physical Medicine and Rehabilitation
Volume 90, Issue 11, Supplement , Pages S3-S10 , November 2009

A Phased Developmental Approach to Neurorehabilitation Research: The Science of Knowledge Building

  • John Whyte, MD, PhD

      Affiliations

    • Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Philadelphia, PA
    • ,
  • Wayne Gordon, PhD, ABPP/Cn (Jack Nash Professor)

      Affiliations

    • Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, NY
    • ,
  • Leslie J. Gonzalez Rothi, PhD

      Affiliations

    • Brain Rehabilitation Research Center, Veterans Affairs Medical Center, Gainesville, FL
    • Department of Neurology, University of Florida, Gainesville, FL
    • Corresponding Author InformationCorrespondence to Leslie J. Gonzalez Rothi, PhD, Brain Rehabilitation Research Center, Malcolm Randall VAMC (151A), 1601 SW Archer Road, Gainesville, FL 32608

References 

  1. Rodriguez AD, Rothi LJ. Principles in conducting rehabilitation research. In:  Stuss DT,  Gordon W,  Robertson I editor. Cognitive neurorehabilitation, evidence and applications. 2nd ed.. New York: Cambridge Univ Pr; 2008;p. 79–90
  2. Robey RR, Schultz MC. A model for conducting clinical-outcome research: an adaptation of the standard protocol for use in aphasiology. Aphasiology. 1998;12:787–810
  3. Whyte J. Rehabilitation effectiveness: the state of the science and a hope for the future. Am J Phys Med Rehabil. 2007;86:835–837
  4. Barrett A, Rothi L. Theoretical bases for neuropsychological interventions. In:  Eslinger PJ editors. Neuropsychological intervention: emerging treatment and management models for neuropsychological impairments. New York: Guilford Pr; 2002;p. 16–37
  5. Barrett AM, Rothi LJ. The changing view of neurorehabilitation: a new era of optimism. J Int Neuropsychol Soc. 2006;12:812–815
  6. Barrett AM, Rothi LJ. Treatment innovation in behavioral rehabilitation of stroke: removing limits on recovery. J Rehabil Res Dev. 2006;43:vii–x
  7. Barrett AM, Levy CE, Rothi LJ. Treatment innovation in rehabilitation of cognitive and motor deficits after stroke and brain injury: physiological adjuncts. Am J Phys Med Rehabil. 2007;86:423–425
  8. Barrett AM, Levy CE, Rothi LJ. Pharmaceuticals for poststroke and brain injury rehabilitation. Am J Phys Med Rehabil. 2007;86:603–604
  9. Barrett AM, Levy CE, Rothi LJ. Poststroke and brain injury rehabilitation treatment strategies. Am J Phys Med Rehabil. 2007;86:694–695
  10. Whyte J. A grand unified theory of rehabilitation (we wish!) (The 57th John Stanley Coulter Memorial Lecture). Arch Phys Med Rehabil. 2008;89:203–209
  11. Travers J, Marsh S, Brent C, et al. External validity of randomized controlled trials in COPD. Respir Med. 2007;101:1313–1320
  12. Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med. 2000;342:1887–1892
  13. Rothi LJ. Cognitive rehabilitation: the role of theoretical rationales and respect for the maturational process needed for our evidence. J Head Trauma Rehabil. 2006;21:194–197
  14. Huff TE. The rise of early modern science: Islam, China and West. 2nd ed.. New York: Cambridge Univ Pr; 2003;
  15. Tschanz DW. Arab roots of European medicine. Heart Views. 2003;4:
  16. Brater DC, Daly WJ. Clinical pharmacology in the middle ages: principles that presage the 21st century. Clin Pharmacol Ther. 2000;67:447–450
  17. Food and Drug Administration. Federal Food, Drug, and Cosmetic Act (FD&C Act). http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCosmeticActFDCAct2009;Accessed July 17, 2009
  18. Bren L. The advancement of controlled trials (FDA Consumer Magazine 2007 (March-April 2007)). http://www.qualitydigest.com/inside/fda-compliance-article/advancement-controlled-clinical-trials.htmlAccessed October 9, 2009
  19. Friedman LM, Furberg DL. Fundamentals of clinical trials. 2nd ed.. St. Louis: Mosby; 1985;
  20. Ruberg SJ. Dose response studies, I: some design considerations. J Biopharm Stat. 1996;6:211–218
  21. Niebuhr BR. Handbook of clinical trial and epidemiological research design. Galveston: University of Texas Medical Branch at Galveston; 2000;
  22. Office of Technology Assessment. Assessing the efficacy and safety of medical technologies. Washington (DC): US Government Printing Office; 1978;Report no. OTA-H-75
  23. Sylvester R, Minder CE. Introduction to the statistical aspects of planning clinical oncologic phase III studies. Urologe A. 1995;34:367–373
  24. Whyte J, Hart T, Bode RK, Malec JF. The Moss Attention Rating Scale (MARS) for traumatic brain injury: initial psychometric assessment. Arch Phys Med Rehabil. 2003;84:268–276
  25. Whyte J. Using treatment theory to refine the designs of brain injury rehabilitation treatment effectiveness studies. J Head Trauma Rehabil. 2006;21:99–106
  26. Kleim JA, Jones TA. Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. J Speech Lang Hear Res. 2008;51:S225–S239
  27. Taub E, Uswatte G, Pidikiti R. Constraint-induced movement therapy: a new family of techniques with broad application to physical rehabilitation—a clinical review. J Rehabil Res Dev. 1999;36:237–251
  28. Behrman AL, Harkema SJ. Locomotor training after human spinal cord injury: a series of case studies. Phys Ther. 2000;80:688–700
  29. Masiero S, Celia A, Rosati G, Armani M. Robotic-assisted rehabilitation of the upper limb after acute stroke. Arch Phys Med Rehabil. 2007;88:142–149
  30. Schallert T, Fleming SM, Leasure JL, Tillerson JL, Bland ST. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology. 2000;39:777–787
  31. Hart T, Fann J, Novack T. The dilemma of the control condition in experience-based cognitive and behavioural treatment research. Neuropsychol Rehabil. 2008;18:1–21

 Supported by grants from the National Institute of Disability and Rehabilitation Research (grant no. H122B040033), United States Department of Education; Veterans Affairs Rehabilitation Research and Development Center of Excellence (grant nos. 2182 and R24 HD050836) from the National Center for Medical Rehabilitation Research.

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.

 Reprints are not available from the author.

PII: S0003-9993(09)00474-2

doi: 10.1016/j.apmr.2009.07.008

Archives of Physical Medicine and Rehabilitation
Volume 90, Issue 11, Supplement , Pages S3-S10 , November 2009

Article Tools