Archives of Physical Medicine and Rehabilitation
Volume 90, Issue 9 , Pages 1478-1488 , September 2009

Physical and Cognitive Functioning After 3 Years Can Be Predicted Using Information From the Diagnostic Process in Recently Diagnosed Multiple Sclerosis

  • Vincent de Groot, MD, PhD

      Affiliations

    • Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
    • EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    • Corresponding Author InformationReprint requests to Vincent de Groot, MD, PhD, Department of Rehabilitation Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    • ,
  • Heleen Beckerman, PT, PhD

      Affiliations

    • Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
    • EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Bernard M. Uitdehaag, MD, PhD

      Affiliations

    • Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    • Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Rogier Q. Hintzen, MD, PhD

      Affiliations

    • Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    • ,
  • Arjan Minneboo, MD

      Affiliations

    • Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Martijn W. Heymans, PhD

      Affiliations

    • EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Gustaaf J. Lankhorst, MD

      Affiliations

    • Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
    • EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Chris H. Polman, MD

      Affiliations

    • Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Lex M. Bouter, PhD

      Affiliations

    • EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Functional Prognostication and Disability (FuPro) Study Group

  • Image Result

    Discrimination (left column) and calibration (right column) curves for all outcomes. The ideal line represents perfect calibration, the apparent line represents our original data and the bias-correcte

    Discrimination (left column) and calibration (right column) curves for all outcomes. The ideal line represents perfect calibration, the apparent line represents our original data and the bias-corrected line represents the bootstrap corrected calibration of the model. (A) Inability to walk at least 500 meters, (B) impaired dexterity, (C) cognitive impairments, (D) incontinence. (E) inability to use a car or public transportation, (F) social dysfunction, (G) reliance on a disability pension.

  • Image Result
    Discrimination (left column) and calibration (right column) curves for all outcomes. The ideal line represents perfect calibration, the apparent line represents our original data and the bias-correcte

    Discrimination (left column) and calibration (right column) curves for all outcomes. The ideal line represents perfect calibration, the apparent line represents our original data and the bias-corrected line represents the bootstrap corrected calibration of the model. (A) Inability to walk at least 500 meters, (B) impaired dexterity, (C) cognitive impairments, (D) incontinence. (E) inability to use a car or public transportation, (F) social dysfunction, (G) reliance on a disability pension.

 Supported by The Netherlands Organization for Scientific Research (grant no. NWO 940-33-009).

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

 The Functional Prognostication and Disability (FuPro) Study Group includes the following investigators: G.J. Lankhorst, J. Dekker, A.J. Dallmeijer, M.J. IJzerman, H. Beckerman, V. de Groot: VU University Medical Center Amsterdam (project coordination); A.J.H. Prevo, E. Lindeman, V.P.M. Schepers: University Medical Center, Utrecht; H.J. Stam, E. Odding, B. van Baalen: Erasmus Medical Center, Rotterdam; A. Beelen, I.J.M. de Groot: Academic Medical Center, Amsterdam.

PII: S0003-9993(09)00397-9

doi: 10.1016/j.apmr.2009.03.018

Archives of Physical Medicine and Rehabilitation
Volume 90, Issue 9 , Pages 1478-1488 , September 2009

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