Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 6 , Pages 1090-1096 , June 2008

The Impact of Female Reproductive Function on Outcomes After Traumatic Brain Injury

Presented to the American Academy of Physical Medicine & Rehabilitation, November 2006, Honolulu, HI.

  • David L. Ripley, MD, MS

      Affiliations

    • Craig Hospital, Englewood, CO
    • Department of Physical Medicine and Rehabilitation, University of Colorado at Denver and Health Sciences Center, Denver, CO.
    • Corresponding Author InformationReprint requests to David L. Ripley, MD, MS, CNS Medical Group, Craig Hospital, 3425 S Clarkson, Englewood, CO 80113
  • ,
  • Cindy Harrison-Felix, PhD

      Affiliations

    • Craig Hospital, Englewood, CO
    • Department of Physical Medicine and Rehabilitation, University of Colorado at Denver and Health Sciences Center, Denver, CO.
  • ,
  • Melissa Sendroy-Terrill, MA

      Affiliations

    • Craig Hospital, Englewood, CO
  • ,
  • Christopher P. Cusick, BA

      Affiliations

    • Craig Hospital, Englewood, CO
  • ,
  • Amy Dannels-McClure, RN, ND

      Affiliations

    • Craig Hospital, Englewood, CO
  • ,
  • Clare Morey, MA, SLP-CCC

      Affiliations

    • Craig Hospital, Englewood, CO

References 

  1. Bell KR, Pepping M. Women and traumatic brain injury. Phys Med Rehabil Clin N Am. 2001;12:169–182
  2. Tate DG, Roller S, Riley B. Quality of life for women with physical disabilities. Phys Med Rehabil Clin N Am. 2001;12:23–37
  3. Ferin M. Clinical review 105: stress and the reproductive cycle. J Clin Endocrinol Metab. 1999;84:1768–1774
  4. Rolih CA, Ober KP. The endocrine response to critical illness. Med Clin North Am. 1995;79:211–224
  5. Bing-You RG, Spratt DI. Serum estradiol but not gonadotropin levels decrease acutely after insulin-induced hypoglycemia in cycling women. J Clin Endocrinol Metab. 1992;75:1054–1059
  6. Burns AS, Jackson AB. Gynecologic and reproductive issues in women with spinal cord injury. Phys Med Rehabil Clin N Am. 2001;12:183–199
  7. Monga TN, Lawson JS, Inglis J. Sexual dysfunction in stroke patients. Arch Phys Med Rehabil. 1986;67:19–22
  8. Sipski ML. Sexual function in women with neurologic disorders. Phys Med Rehabil Clin N Am. 2001;12:79–90
  9. Lieberman SA, Oberoi AL, Gilkison CR, Masel BE, Urban RJ. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab. 2001;86:2752–2756
  10. Cernak I, Savic VJ, Lazarov A, Joksimovic M, Markovic S. Neuroendocrine responses following graded traumatic brain injury in male adults. Brain Inj. 1999;13:1005–1015
  11. Lee SC, Zasler ND, Kreutzer JS. Male pituitary-gonadal dysfunction following severe traumatic brain injury. Brain Inj. 1994;8:571–577
  12. Woolf PD, Hamill RW, McDonald JV, Lee LA, Kelly M. Transient hypogonadotrophic hypogonadism after head trauma: effects on steroid precursors and correlation with sympathetic nervous system activity. Clin Endocrinol (Oxf). 1986;25:265–274
  13. Fleischer AS, Rudman DR, Payne NS, Tindall GT. Hypothalamic hypothyroidism and hypogonadism in prolonged traumatic coma. J Neurosurg. 1978;49:650–657
  14. Richard I, Rome J, Lemené B, Louis F, Perrouin-Verbe B, Mathé JF. [Post-traumatic endocrine deficits: analysis of a series of 93 severe traumatic brain injuries] [French]. Ann Readapt Med Phys. 2001;44:19–25
  15. Alaca R, Yilmaz B, Gunduz S. Anterior hypopituitarism with unusual delayed onset of diabetes insipidus after penetrating head injury. Am J Phys Med Rehabil. 2002;81:788–791
  16. Yuan XQ, Wade CE. Neuroendocrine abnormalities in patients with traumatic brain injury. Front Neuroendocrinol. 1991;12:209–230
  17. Childers MK, Rupright J, Jones PS, Merveille O. Assessment of neuroendocrine dysfunction following traumatic brain injury. Brain Inj. 1998;12:517–523
  18. Zafonte RD, Watanabe TK, Mann NR, Ko DH. Psychogenic polydipsia after traumatic brain injury (A case report). Am J Phys Med Rehabil. 1997;76:246–248
  19. Born JD, Hans P, Smitz S, Legros JJ, Kay S. Syndrome of inappropriate secretion of antidiuretic hormone after severe head injury. Surg Neurol. 1985;23:383–387
  20. Hackl JM, Gottardis M, Wieser C, et al. Endocrine abnormalities in severe traumatic brain injury—a cue to prognosis in severe craniocerebral trauma?. Intensive Care Med. 1991;17:25–29
  21. Grossman WF, Sanfield JA. Hypothalamic atrophy presenting as amenorrhea and sexual infantilism in a female adolescent (A case report). J Reprod Med. 1994;39:738–740
  22. Groswasser Z, Cohen M, Keren O. Female TBI patients recover better than males. Brain Inj. 1998;12:805–808
  23. Wagner AK, Bayir H, Ren D, Puccio A, Zafonte RD, Kochanek PM. Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia. J Neurotrauma. 2004;21:125–136
  24. Subramanian M, Pusphendran CK, Tarachand U, Devasagayam TP. Gestation confers temporary resistance to peroxidation in the maternal rat brain. Neurosci Lett. 1993;155:151–154
  25. Harrison-Felix C, Whiteneck G, DeVivo M, Hammond FM, Jha A. Mortality following rehabilitation in the Traumatic Brain Injury Model Systems of Care. NeuroRehabilitation. 2004;19:45–54
  26. Coimbra R, Hoyt DB, Potenza BM, Fortlage D, Hollingsworth-Fridlund P. Does sexual dimorphism influence outcome of traumatic brain injury patients?. The answer is no! J Trauma. 2003;54:689–700
  27. Sherrill-Pattison S, Donders J, Thompson E. Influence of demographic variables on neuropsychological test performance after traumatic brain injury. Clin Neuropsychol. 2000;14:496–503
  28. Mount DL, Hogg J, Johnstone B. Applicability of the 15-item versions of the Judgement of Line Orientation Test for individuals with traumatic brain injury. Brain Inj. 2002;16:1051–1055
  29. Hibbard MR, Uysal S, Sliwinski M, Gordon WA. Undiagnosed health issues in individuals with traumatic brain injury living in the community. J Head Trauma Rehabil. 1998;13(4):47–57
  30. Whiteneck G, Brooks CA, Mellick D, Harrison-Felix C, Terrill MS, Noble K. Population-based estimates of outcomes after hospitalization for traumatic brain injury in Colorado. Arch Phys Med Rehabil. 2004;85(4 Suppl 2):S73–S81
  31. Farace E, Alves WM. Do women fare worse: a metaanalysis of gender differences in traumatic brain injury outcome. J Neurosurg. 2000;93:539–545
  32. Teasdale G, Jennett B. Assessment of coma and impaired consciousness (A practical scale). Lancet. 1974;2:81–84
  33. Levin HS, O'Donnell VM, Grossman RG. The Galveston Orientation and Amnesia Test (A practical scale to assess cognition after head injury). J Nerv Ment Dis. 1979;167:675–684
  34. Malec J, Lezak M. The Mayo-Portland Adaptability Inventory. http://www.tbims.org/combi/mpai2003;Accessed March 4, 2008
  35. Wilson JT, Pettigrew LE, Teasdale GM. Structured interviews for the Glasgow Outcome Scale and the extended Glasgow Outcome Scale: guidelines for their use. J Neurotrauma. 1998;15:573–585
  36. Pettigrew L, Wilson J, Teasdale G. Reliability of ratings on the Glasgow Outcome Scale from in-person and telephone structured interviews. J Head Trauma Rehabil. 2003;18:252–258
  37. QualityMetric Inc. SF-12v2 Health Survey. http://www.qualitymetric.com/products/surveys/pdf/SF-12v2_Acute_Sample.pdfAccessed January 17, 2005
  38. Findler M, Cantor J, Haddad L, Gordon W, Ashman T. The reliability and validity of the SF-36 health survey questionnaire for use with individuals with traumatic brain injury. Brain Inj. 2001;15:715–723
  39. SPSS 13.0 for Windows (Version 13.0). Chicago: SPSS; 2004;
  40. Bishara SN, Partridge FM, Godfrey HP, Knight RG. Post-traumatic amnesia and Glasgow Coma Scale related to outcome in survivors in a consecutive series of patients with severe closed-head injury. Brain Inj. 1992;6:373–380
  41. Stein D, Hoffman S. Concepts of CNS plasticity in the context of brain damage and repair. J Head Trauma Rehabil. 2003;18:317–341

 Supported by the Colorado Traumatic Brain Injury Trust Fund Research Program.

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

PII: S0003-9993(08)00170-6

doi: 10.1016/j.apmr.2007.10.038

Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 6 , Pages 1090-1096 , June 2008