Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 3 , Pages 422-429 , March 2008

Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050

  • Kathryn Ziegler-Graham, PhD

      Affiliations

    • Department of Mathematics, Statistics and Computer Science, St. Olaf College, Northfield, MN
    • ,
  • Ellen J. MacKenzie, PhD

      Affiliations

    • Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    • Corresponding Author InformationReprint requests to Ellen J. MacKenzie, PhD, Dept of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, 624 N Broadway, Rm 482, Baltimore, MD 21205
    • ,
  • Patti L. Ephraim, MPH

      Affiliations

    • Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    • ,
  • Thomas G. Travison, PhD

      Affiliations

    • New England Research Institutes, Waltham, MA
    • ,
  • Ron Brookmeyer, PhD

      Affiliations

    • Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

  • Image Result

    Schematic illustration of multistate model for limb loss. Transition to limb-loss state occurs with incidence rate. Mortality rate transitions persons without limb loss from the no–limb-loss state to

    Schematic illustration of multistate model for limb loss. Transition to limb-loss state occurs with incidence rate. Mortality rate transitions persons without limb loss from the no–limb-loss state to death, and the transition from limb loss to death is a function of mortality rate and the relative risk of mortality associated with limb loss. Mortality in the limb-loss state is the relative risk multiplied by the background mortality in the no–limb-loss state.

  • Image Result
    Projected number of Americans living with limb amputation secondary to dysvascular disease (log scale) from year 2000 to 2050.

    Projected number of Americans living with limb amputation secondary to dysvascular disease (log scale) from year 2000 to 2050.

 Supported by the U.S. Centers for Disease Control and Prevention (grant no. R04/CCU322981-02).

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(07)01748-0

doi: 10.1016/j.apmr.2007.11.005

Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 3 , Pages 422-429 , March 2008

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