Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 2 , Pages 237-243 , February 2008

Incidence of Fractures in a Cohort of Veterans With Chronic Multiple Sclerosis or Traumatic Spinal Cord Injury

Presented to the American Spinal Association, September 2006, Las Vegas, NV, and the American Geriatrics Association, May 2006, Chicago, IL.

  • William C. Logan Jr, MD

      Affiliations

    • Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, NC
    • Geriatric Research Education and Clinical Center, Durham VA Medical Center, Durham, NC
    • Division of Geriatrics, Greenville Hospital System/University Medical Center, Greenville, SC
    • Corresponding Author InformationReprint requests to William C. Logan, Jr, MD, Division of Geriatrics, Greenville Hospital System/University Medical Center, Center for Success in Aging, 255 Enterprise Blvd., Suite 101, Greenville, SC 29615
    • ,
  • Richard Sloane, MS

      Affiliations

    • Center for the Study of Aging and Human Development, Duke University, Durham, NC
    • ,
  • Kenneth W. Lyles, MD

      Affiliations

    • Endocrinology and Geriatrics, Duke University Medical Center, Durham, NC
    • ,
  • Barry Goldstein, MD, PhD

      Affiliations

    • Spinal Cord Injury and Disorders Strategic Healthcare Group, Department of Veterans Affairs, Puget Sound Health Care System, Seattle, WA
    • ,
  • Helen M. Hoenig, MD, MPH

      Affiliations

    • Duke University Medical Center, Durham, NC
    • Physical Medicine and Rehabilitation, Durham VA Medical Center, Durham, NC.

  • Image Result

    Location of fracture by cause of SCD. Proportion of fractures for MS (n=219) and SCI (n=1519). NOTE. Overall difference in distribution of fractures was significant (Cochran-Mantel-Haenszel, P<.001).

    Location of fracture by cause of SCD. Proportion of fractures for MS (n=219) and SCI (n=1519). NOTE. Overall difference in distribution of fractures was significant (Cochran-Mantel-Haenszel, P<.001). Abbreviations: Ext, extremity; Fem Sft Dist, femoral shaft and distal femur; Fx, fracture; Other, includes clavicle, scapula, and unclassifiable fractures; Prox Fem, proximal femur; Tib/Fib, tibia and fibula.

  • Image Result
    Fracture rates by cause and degree of impairment. Measure fracture rates per 100 patient-years at risk among the surviving members of our cohort stratified by degree of motor impairment and cause of S

    Fracture rates by cause and degree of impairment. Measure fracture rates per 100 patient-years at risk among the surviving members of our cohort stratified by degree of motor impairment and cause of SCD. Abbreviation: Imp, impairment.

  • Image Result
    Time to first fracture by cause and degree of impairment. (A) Time to first fracture by degree of motor impairment. “Some” and “moderate” impairment had the shortest time to first fracture. (B) Time t

    Time to first fracture by cause and degree of impairment. (A) Time to first fracture by degree of motor impairment. “Some” and “moderate” impairment had the shortest time to first fracture. (B) Time to first fracture by cause of SCD. Those with trauma had a shorter time to fracture than those with MS.

 Supported by the Center For the Study of Aging and Human Development.A commercial party having a direct financial interest in the results of the research supporting this article has conferred or will confer a financial benefit upon the author or one or more of the authors. Lyles has received financial support from Novartis, the Alliance for Better Bone Health, and Amgen; he is a consultant to Novartis, Procter & Gamble, Merck, Amgen, GTx, and Bone Medical Ltd; he holds U.S. patent 20050272707 (methods for preventing or reducing secondary fractures after hip fracture); and has a provisional patent application (medications kits and formulations for preventing, treating, or reducing secondary fractures after previous fracture).

PII: S0003-9993(07)01654-1

doi: 10.1016/j.apmr.2007.08.144

Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 2 , Pages 237-243 , February 2008

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