Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 1 , Pages 36-41 , January 2008

Elevated C-Reactive Protein Associated With Decreased High-Density Lipoprotein Cholesterol in Men With Spinal Cord Injury

  • Huifang Liang, MD, PhD

      Affiliations

    • Department of Human Nutrition, University of Illinois, Chicago, IL
    • ,
  • Mina C. Mojtahedi, MS

      Affiliations

    • Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, IL
    • ,
  • David Chen, MD

      Affiliations

    • Spinal Cord Injury Acute Care and Rehabilitation, Northwestern Memorial Hospital and Rehabilitation Institute of Chicago, Chicago, IL.
    • ,
  • Carol L. Braunschweig, PhD, RD

      Affiliations

    • Department of Human Nutrition, University of Illinois, Chicago, IL
    • Corresponding Author InformationReprint requests to Carol L. Braunschweig, PhD, RD, Dept of Human Nutrition, University of Illinois, 1919 W Taylor St, Rm 650 (M/C 517), Chicago, IL 60612

References 

  1. Kocina P. Body composition of spinal cord injured adults. Sports Med. 1997;23:48–60
  2. Bauman WA, Spungen AM. Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: a model of premature aging. Metabolism. 1994;43:749–756
  3. Imai K, Kadowaki T, Aizawa Y. Standardized indices of mortality among persons with spinal cord injury: accelerated aging process. Ind Health. 2004;42:213–218
  4. Garshick E, Kelley A, Cohen SA, et al. A prospective assessment of mortality in chronic spinal cord injury. Spinal Cord. 2005;43:408–416
  5. Liang H, Chen D, Wang Y, Rimmer JH, Braunschweig CL. Different risk factor patterns for metabolic syndrome in men with spinal cord injury compared with able-bodied men despite similar prevalence rates. Arch Phys Med Rehabil. 2007;88:1198–1204
  6. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99:237–242
  7. Sakkinen P, Abbott RD, Curb JD, Rodriguez BL, Yano K, Tracy RP. C-reactive protein and myocardial infarction. J Clin Epidemiol. 2002;55:445–451
  8. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557–1565
  9. Folsom AR, Aleksic N, Catellier D, Juneja HS, Wu KK. C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study. Am Heart J. 2002;144:233–238
  10. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation. 1998;97:2007–2011
  11. Centers for Disease Control and Prevention; American Heart AssociationPearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107:499–511
  12. Frost F, Roach MJ, Kushner I, Schreiber P. Inflammatory C-reactive protein and cytokine levels in asymptomatic people with chronic spinal cord injury. Arch Phys Med Rehabil. 2005;86:312–317
  13. Manns PJ, McCubbin JA, Williams DP. Fitness, inflammation, and the metabolic syndrome in men with paraplegia. Arch Phys Med Rehabil. 2005;86:1176–1181
  14. Lee MY, Myers J, Hayes A, et al. C-reactive protein, metabolic syndrome, and insulin resistance in individuals with spinal cord injury. J Spinal Cord Med. 2005;28:20–25
  15. Hansel B, Kontush A, Bonnefont-Rousselot D, Bruckert E, Chapman MJ. Alterations in lipoprotein defense against oxidative stress in metabolic syndrome. Curr Atheroscler Rep. 2006;8:501–509
  16. Rohrer L, Hersberger M, von Eckardstein A. High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease. Curr Opin Lipidol. 2004;15:269–278
  17. Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58:342–374
  18. Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Ansell BJ, Fogelman AM. Mechanisms of disease: proatherogenic HDL—an evolving field. Nat Clin Pract Endocrinol Metab. 2006;2:504–511
  19. Georgiadis AN, Papavasiliou EC, Lourida ES, et al. Atherogenic lipid profile is a feature characteristic of patients with early rheumatoid arthritis: effect of early treatment—a prospective, controlled study. Arthritis Res Ther. 2006;8:R82
  20. LaPorte RE, Brenes G, Dearwater S, et al. HDL cholesterol across a spectrum of physical activity from quadriplegia to marathon running. Lancet. 1983;1:1212–1213
  21. Dearwater SR, LaPorte RE, Robertson RJ, Brenes G, Adams LL, Becker D. Activity in the spinal cord-injured patient: an epidemiologic analysis of metabolic parameters. Med Sci Sports Exerc. 1986;18:541–544
  22. Bauman WA, Adkins RH, Spungen AM, Kemp BJ, Waters RL. The effect of residual neurological deficit on serum lipoproteins in individuals with chronic spinal cord injury. Spinal Cord. 1998;36:13–17
  23. Bauman WA, Adkins RH, Spungen AM, Maloney P, Gambino R, Waters RL. Ethnicity effect on the serum lipid profile in persons with spinal cord injury. Arch Phys Med Rehabil. 1998;79:176–180
  24. Ford ES, Giles WH, Myers GL, Mannino DM. Population distribution of high-sensitivity C-reactive protein among US men: findings from National Health and Nutrition Examination Survey 1999-2000. Clin Chem. 2003;49:686–690
  25. Kushner I. C-reactive protein and the acute-phase response. Hosp Pract (Off Ed). 1990;25:13;6, 21-8
  26. National Center for Health Statistics, Centers for Disease Control and Prevention, National Center for Health Statistics. National Health and Nutrition Examination Survey data. Hyattsville: U.S. Department of Health and Human Services, CDC; 1999-2000, 2001-2002. http://www.cdc.gov/nchs/about/major/nhanes/datalink.htmAccessed August 15, 2006
  27. Shahabi S, Hassan ZM, Jazani NH, Ebtekar M. Sympathetic nervous system plays an important role in the relationship between immune mediated diseases. Med Hypotheses. 2006;67:900–903
  28. Haug SR, Heyeraas KJ. Modulation of dental inflammation by the sympathetic nervous system. J Dent Res. 2006;85:488–495
  29. American Spinal Injury Association. International standards for neurological classification of spinal cord injury. 5th ed.. Chicago: ASIA; 2000;
  30. Chumlea WC, Roche AF, Mukherjee D, Steinbaugh ML. Errors of measurement for methods of recumbent nutritional anthropometry in the elderly. J Nutr Elder. 1985;5:3–11
  31. Williamson DF, Kahn HS, Worthman CM, Burnette JC, Russell CM. Precision of recumbent anthropometry. Am J Hum Biol. 1993;15:159–167
  32. Ford ES, Giles WH, Mokdad AH. Family history of diabetes or cardiovascular disease and C-reactive protein concentration: findings from the National Health and Nutrition Examination Survey, 1999-2000. Am J Prev Med. 2005;29(5 Suppl 1):57–62
  33. Carroll MD, Lacher DA, Sorlie PD, et al. Trends in serum lipids and lipoproteins of adults, 1960-2002. JAMA. 2005;294:1773–1781
  34. Washburn RA, Zhu W, McAuley E, Frogley M, Figoni SF. The physical activity scale for individuals with physical disabilities: development and evaluation. Arch Phys Med Rehabil. 2002;83:193–200
  35. Ainsworth BE, Haskell WL, Leon AS, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25:71–80
  36. Myers GL, Rifai N, Tracy RP, et al. CDC, AHA (CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the laboratory science discussion group). Circulation. 2004;110:e545–e549
  37. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda: National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; 2001;
  38. Plaisance EP, Grandjean PW. Physical activity and high-sensitivity C-reactive protein. Sports Med. 2006;36:443–458
  39. Chrysohoou C, Pitsavos C, Skoumas J, et al. The emerging anti-inflammatory role of HDL-cholesterol, illustrated in cardiovascular disease free population; the ATTICA study. Int J Cardiol. 2007;122:29–33
  40. Khera A, de Lemos JA, Peshock RM, et al. Relationship between C-reactive protein and subclinical atherosclerosis: the Dallas Heart Study. Circulation. 2006;113:38–43
  41. Chung CP, Oeser A, Solus JF, et al. Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis In press.
  42. McMahon M, Grossman J, FitzGerald J, et al. Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 2006;54:2541–2549
  43. Budoff MJ, Shinbane JS, Child J, et al. Multiphase contrast medium injection for optimization of computed tomographic coronary angiography. Acad Radiol. 2006;13:159–165
  44. Orakzai SH, Orakzai RH, Ahmadi N, et al. Measurement of coronary artery calcification by electron beam computerized tomography in persons with chronic spinal cord injury: evidence for increased atherosclerotic burden. Spinal Cord. In press.

 Supported by the Agency for Healthcare Research and Quality, National Institutes of Health (grant no. R03HS011277-01).No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(07)01593-6

doi: 10.1016/j.apmr.2007.08.121

Archives of Physical Medicine and Rehabilitation
Volume 89, Issue 1 , Pages 36-41 , January 2008

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