Archives of Physical Medicine and Rehabilitation
Volume 88, Issue 11 , Pages 1416-1422 , November 2007

Exercise Prevents Fatigue and Improves Quality of Life in Prostate Cancer Patients Undergoing Radiotherapy

  • Uma Monga, MD

      Affiliations

    • Diagnostic and Therapeutic Care Line (Radiotherapy Section), Michael E. DeBakey VA Medical Center, Houston TX
  • ,
  • Susan L. Garber, MA, OTR

      Affiliations

    • Research Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
  • ,
  • John Thornby, PhD

      Affiliations

    • Research Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX.
  • ,
  • Carlos Vallbona, MD

      Affiliations

    • Rehabilitation Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
    • Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX.
  • ,
  • Anthony J. Kerrigan, PhD

      Affiliations

    • Mental Health Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
  • ,
  • Trilok N. Monga, MD

      Affiliations

    • Rehabilitation Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Radiology, Baylor College of Medicine, Houston, TX
    • Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
  • ,
  • Kuno P. Zimmermann, DO, PhD

      Affiliations

    • Rehabilitation Care Line, Michael E. DeBakey VA Medical Center, Houston TX
    • Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX
    • Corresponding Author InformationReprint requests to Kuno P. Zimmermann, DO, PhD, Rehabilitation Care Line (117), Michael E. DeBakey Department of Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77030

References 

  1. Young RC. Cancer statistics: progress or cause for concern?. CA Cancer J Clin. 2002;52:6–7
  2. Smets EM, Garssen B, Schuster-Uitterhoeve AL, de Haes JC. Fatigue in cancer patients. Br J Cancer. 1993;68:220–224
  3. Richardson A. Fatigue in cancer patients: a review of the literature. Eur J Cancer Care (Engl). 1995;4:20–32
  4. Vogelzang NJ, Breitbart W, Cella D, et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. Semin Hematol. 1997;34(3 Suppl 2):4–12
  5. Monga U, Jaweed M, Kerrigan AJ, et al. Neuromuscular fatigue in prostate cancer patients undergoing radiotherapy. Arch Phys Med Rehabil. 1997;78:961–966
  6. Monga U, Kerrigan AJ, Thornby J, Monga TN. Prospective study of fatigue in localized prostate cancer patients undergoing radiotherapy. Radiat Oncol Investig. 1999;7:178–185
  7. Monga U, Kerrigan AJ, Thornby J, Monga TN, Zimmermann KP. Longitudinal study of quality of life in patients with localized prostate cancer undergoing radiotherapy. J Rehabil Res Dev. 2005;42:391–399
  8. Miller DC, Sanda MG, Dunn RL, et al. Long term outcomes among localized prostate cancer survivors: health related quality of life changes after prostatectomy, external radiation and brachytherapy. J Clin Oncol. 2005;23:2772–2780
  9. Piper BF, Lindsey AM, Dodd MJ, Ferketich MJ, Paul SM, Weller S. Key aspects of comfort: management of pain, fatigue, and nausea. In:  Funk SG,  Tornquist EM,  Champagne MT,  Copp LA,  Wiese RA editor. The development of an instrument to measure the subjective dimension of fatigue. New York: Springer; 1989;p. 199–208
  10. Haylock PJ, Hart LK. Fatigue in patients receiving localized radiation. Cancer Nurs. 1979;2:461–467
  11. King KB, Nail LM, Kreamer K, Strohl RA, Johnson JE. Patients’ descriptions of the experience of receiving radiation therapy. Oncol Nurs Forum. 1985;12(4):55–61
  12. Kobashi-Schoot JA, Hanewald GJ, van Dam FS, Bruning PF. Assessment of malaise in cancer patients treated with radiotherapy. Cancer Nurs. 1985;8:306–313
  13. Vallbona C. Krusen’s handbook of physical medicine and rehabilitation. In:  Kottke FJ,  Stillwell GK,  Lehman JF editor. Bodily responses to immobilization. 3rd ed.. New York: WB Saunders; 1982;p. 963–975
  14. MacVicar MG, Winningham ML, Nickel JL. Effects of aerobic interval training on cancer patients’ functional capacity. Nurs Res. 1989;38:348–351
  15. Byrne A, Byrne DG. The effect of exercise on depression, anxiety, and other mood states: a review. J Psychosom Res. 1993;37:565–574
  16. King AC, Taylor CB, Haskell WL. Effects of differing intensities and formats of 12 months of exercise training on psychological outcomes in older adults. Health Psychol. 1993;12:292–300
  17. Blanchard CM, Courneya KS, Laing D. Effects of acute exercise on state anxiety in breast cancer survivors. Oncol Nurs Forum. 2001;28:1617–1621
  18. Blumenthal JA, Williams RS, Needels TL, Wallace AG. Psychological changes accompany aerobic exercise in healthy middle-aged adults. Psychosom Med. 1982;44:529–536
  19. Singh NA, Clements KM, Fiatarone MA. A randomized controlled trial of progressive resistance training in depressed elders. Gerontol A Biol Sci Med Sci. 1997;52:M27–M35
  20. MacVicar MG, Winningham ML. Promoting the functional capacity of cancer patients. Cancer Bull. 1986;38:235–239
  21. Mock V, Burke MB, Sheehan P, et al. A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum. 1994;21:899–907
  22. Burnham TR, Wilcox A. Effects of exercise on physiological and psychological variables in cancer survivors. Med Sci Sports Exerc. 2002;34:1863–1867
  23. Pinto BM, Clark MM, Maruyama NC, Feder SI. Psychological and fitness changes associated with exercise participation among women with breast cancer. Psychooncology. 2003;12:118–126
  24. Schwartz AL, Mori M, Gao R, Nail LM, King ME. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc. 2001;33:718–723
  25. Young-McCaughan S, Sexton DL. A retrospective investigation of the relationship between aerobic exercise and quality of life in women with breast cancer. Oncol Nurs Forum. 1991;18:751–757
  26. Courneya KS, Mackey JR, Bell GJ, Jones LW, Field CJ, Fairey AS. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol. 2003;21:1660–1668
  27. Friedenreich CM, Courneya KS. Exercise as rehabilitation for cancer patients. Clin J Sport Med. 1996;6:237–244
  28. Karvonen M, Kentala K, Mustala O. The effects of training heart rate: a longitudinal study. Ann Med Exp Biol Fenn. 1957;35:307–315
  29. Bruce RA. Exercise testing for evaluation of ventricular function. N Engl J Med. 1977;296:671–675
  30. Hopkins DR, Hoeger WW. Lifetime physical fitness and wellness. In:  Hoeger WW editors. The modified sit and reach test. Englewood: Morton Publishing; 1986;p. 47–48
  31. Hoeger WW, Hopkins DR. A comparison of the sit and reach and the modified sit and reach in the measurement of flexibility in women. Res Q Exerc Sport. 1992;63:191–195
  32. Nevitt MC, Cummings SR, Kidd S, Black D. Risk factors for recurrent nonsyncopal falls: a prospective study. JAMA. 1989;261:2663–2668
  33. Esper P, Mo F, Chodak G, Sinner M, Cella D, Pienta KJ. Measuring quality of life in men with prostate cancer using the functional assessment of cancer therapy–prostate instrument. Urology. 1997;50:920–928
  34. Cella DF, Tulsky DS, Gray G, et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11:570–579
  35. Weitzner MA, Meyers CA, Gelke CK, Byrne KS, Cella DF, Levin VA. The Functional Assessment of Cancer Therapy (FACT) Scale: development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer. 1995;75:1151–1161
  36. Beck AT. Depression: causes and treatment. Philadelphia: Univ Pennsylvania Pr; 1970;
  37. Kendall PC, Hollon SD, Beck AT, Hammen CL, Ingram RE. Issues and recommendations regarding use of the Beck Depression Inventory. Cognit Ther Res. 1987;11:289–299
  38. Marsella AJ, Sanborn KO, Kameoka V, Shizuru L, Brennan J. Cross-validation of self-report measures of depression among normal populations of Japanese, Chinese, and Caucasian ancestry. J Clin Psychol. 1975;31:281–287
  39. Reynolds WM, Gould JW. A psychometric investigation of the standard and short form Beck Depression Inventory. J Consult Clin Psychol. 1981;49:306–307
  40. Winningham ML, MacVicar MG, Bondoc M, Anderson JI, Minton JP. Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapy. Oncol Nurs Forum. 1989;16:683–689
  41. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr. 2002;132(11 Suppl):3456S–3464S
  42. Johnson JB, Kelly AW. A multifaceted rehabilitation program for women with cancer. Oncol Nurs Forum. 1990;17:691–695
  43. Molinaro J, Kleinfeld M, Lebed S. Physical therapy and dance in the surgical management of breast cancer: a clinical report. Phys Ther. 1986;66:967–969
  44. Watson PG. The optimal functioning plan: a key element in cancer rehabilitation. Cancer Nurs. 1992;15:254–263
  45. Courneya KS, Friedenreich CM. Physical exercise and quality of life following cancer diagnosis: a literature review. Ann Behav Med. 1999;21:171–179
  46. Segal RJ, Reid RD, Courneya KS, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003;21:1653–1659
  47. Meyer TJ, Mark MM. Effects of psychosocial interventions with adult cancer patients: a meta-analysis of randomized experiments. Health Psychol. 1995;14:101–108
  48. Cella DF, Tulsky DS. Measuring quality of life today: methodological aspects. Oncology. 1990;4(5):29–38

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(07)01448-7

doi: 10.1016/j.apmr.2007.08.110

Archives of Physical Medicine and Rehabilitation
Volume 88, Issue 11 , Pages 1416-1422 , November 2007