Archives of Physical Medicine and Rehabilitation
Volume 88, Issue 11 , Pages 1384-1393 , November 2007

Clinical Correlates of Elevated Serum Concentrations of Cytokines and Autoantibodies in Patients With Spinal Cord Injury

  • Andrew L. Davies, MSc

      Affiliations

    • Graduate Program in Neuroscience, London, ON, Canada
    • University of Western Ontario, London, ON, Canada.
    • ,
  • Keith C. Hayes, PhD

      Affiliations

    • Department of Physical Medicine & Rehabilitation, London, ON, Canada
    • Lawson Health Research Institute, London, ON, Canada
    • University of Western Ontario, London, ON, Canada.
    • Corresponding Author InformationReprint requests to Keith C. Hayes, PhD, Parkwood Hospital/SJHC, 801 Commissioners Rd E, London, ON N6C 5J1, Canada
    • ,
  • Gregory A. Dekaban, PhD

      Affiliations

    • Department of Microbiology and Immunology, London, ON, Canada
    • Biotherapeutics Research Group, Robarts Research Institute, London, ON, Canada
    • University of Western Ontario, London, ON, Canada.

  • Image Result

    Serum cytokine concentrations for control subjects and SCI patients (all). (A) IL-2, (B) IL-6, (C) TNF-α, and (D) IL-1RA. Note that all serum cytokine concentrations have been transformed to their nat

    Serum cytokine concentrations for control subjects and SCI patients (all). (A) IL-2, (B) IL-6, (C) TNF-α, and (D) IL-1RA. Note that all serum cytokine concentrations have been transformed to their natural logarithm (In) values. *P<.05 (Kruskal-Wallis ANOVA).

  • Image Result
    Serum cytokine concentrations of (A) IL-6 and (B) IL-1RA for control subjects and SCI subjects categorized according to the presence or absence of the medical complication of UTI, pressure ulcers, or

    Serum cytokine concentrations of (A) IL-6 and (B) IL-1RA for control subjects and SCI subjects categorized according to the presence or absence of the medical complication of UTI, pressure ulcers, or pain. Note that all serum cytokine concentrations have been transformed to their natural logarithm (In) values. *P<.05 (Kruskal-Wallis ANOVA).

  • Image Result
    Serum concentration of anti-GM1 (1gG) for control subjects and SCI subjects (all). Abbreviation: BTU, Bühlmann titer units. *P<.05 (Kruskal-Wallis ANOVA).

    Serum concentration of anti-GM1 (1gG) for control subjects and SCI subjects (all). Abbreviation: BTU, Bühlmann titer units. *P<.05 (Kruskal-Wallis ANOVA).

 Supported by the Parkwood Hospital Foundation and the Ontario Neurotrauma Foundation.

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(07)01342-1

doi: 10.1016/j.apmr.2007.08.004

Archives of Physical Medicine and Rehabilitation
Volume 88, Issue 11 , Pages 1384-1393 , November 2007

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