Development of a French Isometric Strength Normative Database for Adults Using Quantitative Muscle Testing
Abstract
Hogrel J-Y, Payan CA, Ollivier G, Tanant V, Attarian S, Couillandre A, Dupeyron A, Lacomblez L, Doppler V, Meininger V, Tranchant C, Pouget J, Desnuelle C. Development of a French isometric strength normative database for adults using quantitative muscle testing.
Objective
To establish a normative database for isometric strength measured by quantitative muscle testing (QMT) for a French adult population.
Design
Measurement of maximal voluntary isometric contraction.
Setting
Four clinical centers involved in neuromuscular disorders.
Participants
A total of 315 healthy adults (147 men, 168 women) ages 20 to 80 years.
Interventions
Not applicable.
Main Outcome Measure
Isometric torque values of 14 muscle functions (13 bilaterally and neck).
Results
This study led to the development of a French isometric strength normative database for adults measured by QMT. For each muscle function, predictive regression models using age, sex, and weight are proposed. Some methodologic issues concerning strength measurement are discussed.
Conclusions
This database can be used to compute relative deficits in muscle strength for 27 muscle functions and also to estimate composite scores for follow-up of patients either during the natural history of their disease or during a therapeutic trial.
aInstitut de Myologie, GH Pitié-Salpêtrière, Paris, France
bDépartement de Pharmacologie Clinique, GH Pitié-Salpêtrière, Paris, France
cFédération des Maladies du Système Nerveux, GH Pitié-Salpêtrière, Paris, France
dCentre de Référence Maladies Neuromusculaires, Hôpital de l’Archet, Nice, France
eService de Neurologie, CHU La Timone, Marseille, France
fService de Neurologie, CHU de Strasbourg, Strasbourg, France.
Reprint requests to Jean-Yves Hogrel, PhD, Institut de Myologie, GH Pitié-Salpêtrière, 75651 Paris Cedex 13, France
Supported by the Association de Recherche sur la Sclérose Latérale Amyotrophique and the Association Française contre les Myopathies.
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.