Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12 , Pages 1611-1617 , December 2006

Functional Outcomes and Life Satisfaction in Long-Term Survivors of Pediatric Sarcomas

  • Lynn H. Gerber, MD

      Affiliations

    • Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
    • Corresponding Author InformationReprint requests to Lynn H. Gerber, MD, Center for the Study of Chronic Illness and Disability, George Mason University, 4400 University Dr, MSN 5B7, Fairfax, VA 22030
  • ,
  • Karen Hoffman, MD

      Affiliations

    • Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
  • ,
  • Usha Chaudhry, MD

      Affiliations

    • Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
  • ,
  • Elizabeth Augustine, PT

      Affiliations

    • Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
  • ,
  • Rebecca Parks, OT

      Affiliations

    • Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
  • ,
  • Martha Bernad, DSc

      Affiliations

    • Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD
  • ,
  • Crystal Mackall, MD

      Affiliations

    • Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
  • ,
  • Seth Steinberg, PhD

      Affiliations

    • Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
  • ,
  • Patrick Mansky, MD

      Affiliations

    • National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD

References 

  1. Bleyer WA. Cancer in older adolescents and young adults: epidemiology, diagnosis, treatment, survival, and importance of clinical trials. Med Pediatr Oncol. 2002;38:1–10
  2. Hudson MM, Mertens AC, Yasui Y, et al. Health status of adult long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. JAMA. 2003;290:1583–1592
  3. Schwartz CL. Long term survivors of childhood cancer: the late effects of therapy. Oncologist. 1999;4:45–54
  4. Novakovic B, Fears TR, Horowitz ME, Tucker MA, Wexler LH. Late effects of therapy in survivors of Ewing’s sarcoma family tumors. J Pediatr Hematol Oncol. 1997;19:220–225
  5. Green DM, Hyland A, Chung CS, Zevon MA, Hall BC. Cancer and cardiac mortality among 15-year survivors of cancer diagnosed during childhood or adolescence. J Clin Oncol. 1999;17:3207–3215
  6. Hogarty AN, Silber JH, Paridon SM. Cardiopulmonary exercise testing in the evaluation of the functional capacity of survivors of childhood cancer. Prog Pediatr Cardiol. 1998;8:109–119
  7. Gotay CC, Muraoka MY. Quality of life in long-term survivors of adult-onset cancers. J Natl Cancer Inst. 1998;90:656–667
  8. Apajasalo M, Sintonen H, Siimes MA, et al. Health-related quality of life of adults surviving malignancies in childhood. Eur J Cancer. 1996;32A:1354–1358
  9. Dolgin MJ, Somer E, Buchvald E, Zaizov R. Quality of life in adult survivors of childhood cancer. Soc Work Health Care. 1999;28:31–43
  10. Elkin TD, Phipps S, Mulhern RK, Fairclough D. Psychological functioning of adolescent and young adult survivors of pediatric malignancy. Med Pediatr Oncol. 1997;29:582–588
  11. Meadows AT, McKee L, Kazak AE. Psychosocial status of young adult survivors of childhood cancer: a survey. Med Pediatr Oncol. 1989;17:466–470
  12. Tebbi CK, Bromberg C, Piedmonte M. Long-term vocational adjustment of cancer patients diagnosed during adolescence. Cancer. 1989;63:213–218
  13. Nagarajan R, Neglia JP, Cloluis DR, et al. Education, employment, insurance, marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study. Cancer. 2003;97:2554–2564
  14. Boman KK, Bodegard G. Life after cancer in childhood: social adjustment, educational and vocational status of young adult survivors. J Pediatr Hematol Oncol. 2004;26:354–362
  15. Hovi L, Era P, Rautonen J, Siimes MA. Impaired muscle strength in female adolescents and young adults surviving leukemia in childhood. Cancer. 1993;72:276–281
  16. Talvensaari KK, Jamsen A, Vanharanta H, Lanning M. Decreased isokinetic trunk muscle strength and performance in long-term survivors of childhood malignancies: correlation with hormonal defects. Arch Phys Med Rehabil. 1995;76:983–988
  17. Lampert MH, Gerber LH, Glatstein E, Rosenberg SA, Danoff JV. Soft tissue sarcoma: functional outcome after wide local excision and radiation therapy. Arch Phys Med Rehabil. 1984;65:477–480
  18. Nybo H, Petersen HC, Gaist D, et al. Predictors of mortality in 224 nonagenarians—the Danish 1905 Cohort Survey. J Am Geriatr Soc. 2003;51:1365–1373
  19. Morey MC, Pieper CF, Crowley GM, Sullivan RJ, Puglisi CM. Exercise adherence and 10-year mortality in chronically ill older adults. J Am Geriatr Soc. 2002;50:1929–1933
  20. Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KM. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med. 2003;163:1440–1447
  21. Bohannon RW, Lee N, Maljanian R. Postadmission function best predicts acute hospital outcomes after stroke. Am J Phys Med Rehabil. 2002;81:726–730
  22. Metter EJ, Talbot LA, Schrager M, Conwit R. Skeletal muscle strength, as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci. 2002;57:B359–B365
  23. Melzer D, Lan TY, Guralnik JM. The predictive validity for mortality of the index of mobility-related limitation—results from the EPESE study. Age Ageing. 2003;32:619–625
  24. Mansky PJ, Hoffman K, Derdak J, et al. Preserved functionality and increased cardiovascular risk in pediatric sarcoma long term survivors. Proc Am Soc Clin Oncol. 2003;22:3261
  25. Waters RL, Lunsford BR, Perry J, Byrd R. Energy-speed relationship of walking: standard tables. J Orthop Res. 1988;6:215–222
  26. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166:111–117
  27. Kendall F, McCreary E, Provance P. Muscle testing and function. 4th ed.. Baltimore: Williams & Wilkins; 1999;
  28. Mathiowetz V, Wiemer DM, Federman SM. Grip and pinch strength: norms for 6- to 19-year-olds. Am J Occup Ther. 1986;40:705–711
  29. Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S. Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil. 1985;66:69–74
  30. Joint motion: method of measuring and recording. Chicago: American Academy of Orthopaedic Surgeons; 1965;
  31. PeroPlus 2000 US: manual type 400T. Wuppertal: Pero-System Messegerate GmbH; 1999;
  32. Fisher A. The assessment of motor and process skills. Ft. Collins: Three Stars Pr; 1999;
  33. Fix AJ, Daughton DM. Human Activity Profile: professional manual. Odessa: Psychological Assessment Resources; 1988;
  34. Leisure Satisfaction Measure. Enumclaw: Idyll Arbor; 1991;
  35. Beard JG, Ragheb MG. Measuring leisure satisfaction. J Leisure Res. 1980;12:20–33
  36. Ware J, Kosinski M, Dewey J. How to score version two of the SF-36 Health Survey. Lincoln: Quality Metric Inc; 2000;
  37. Jenkinson C, Coulter A, Wright L. Short form (SF36) health survey questionnaire: normative data for adults of working age. BMJ. 1993;306:1437–1440
  38. Bergner M, Bobbitt RA, Carter WB, Gilson BS. The Sickness Impact Profile: development and final revision of a health status measure. Med Care. 1981;19:787–805
  39. Goldberg RT. The Goldberg Scale of Vocational Development. Self-published; 1973.
  40. Kielhofner G, Mallinson T, Crawford C, et al. A user’s manual for the Occupational Performance History Interview (Version 2.0), OPHI-II. Chicago: Model of Human Occupation Clearinghouse, University of Illinois; 1998;
  41. Syddall H, Cooper C, Martin F, Briggs R, Aihie Sayer A. Is grip strength a useful single marker of frailty?. Age Aging. 2003;32:650–656
  42. Davis AM, Sennik S, Griffin AM, et al. Predictors of functional outcomes following limb salvage surgery for lower-extremity soft tissue sarcoma. J Surg Oncol. 2000;73:206–211
  43. Gerrand CH, Wunder JS, Kandel RA, et al. The influence of anatomic location on functional outcome in lower-extremity soft-tissue sarcoma. Ann Surg Oncol. 2004;11:476–482
  44. Larcombe I, Mott M, Hunt L. Lifestyle behaviors of young adult survivors of childhood cancer. Br J Cancer. 2002;87:1204–1209
  45. Zebrack BJ, Chester MA. Health-related worries self-image and life outlooks of long-term survivors of childhood cancer. Health Soc Work. 2001;26:245–257
  46. Zebrack BJ, Chestler MA. Quality of life in childhood cancer survivors. Psychooncology. 2002;11:132–141
  47. Schwartz CL. Health status of childhood cancer survivors. JAMA. 2003;290:1641–1643
  48. Mansky P, Arai A, Stratton P, et al. Treatment late effects in long-term survivors of pediatric sarcoma. Pediatr Blood Cancer. In press.
  49. Carnethon MR, Gidding SS, Nehgme R, Sidney S, Jacobs DR, Liu K. Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors. JAMA. 2003;290:3092–3100

 Supported by the National Institutes of Health (intramural grant).No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)01324-4

doi: 10.1016/j.apmr.2006.08.341

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12 , Pages 1611-1617 , December 2006