Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12, Supplement , Pages 50-58 , December 2006

Susceptibility-Weighted Imaging and Proton Magnetic Resonance Spectroscopy in Assessment of Outcome After Pediatric Traumatic Brain Injury

  • Stephen Ashwal, MD

      Affiliations

    • Department of Pediatrics, Division of Child Neurology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA
    • Corresponding Author InformationCorrespondence to Stephen Ashwal, MD, Dept of Pediatrics, Loma Linda University School of Medicine, 11175 Campus St, Loma Linda, CA 92350
  • ,
  • Talin Babikian, PhD

      Affiliations

    • Department of Clinical Psychology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA
  • ,
  • Joy Gardner-Nichols, PhD

      Affiliations

    • Department of Clinical Psychology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA
  • ,
  • Mary-Catherine Freier, PhD

      Affiliations

    • Department of Clinical Psychology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA
  • ,
  • Karen A. Tong, MD

      Affiliations

    • Department of Radiology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA
  • ,
  • Barbara A. Holshouser, PhD

      Affiliations

    • Department of Radiology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA

References 

  1. Broman S, Michel M. Traumatic head injury in children. New York: Oxford Univ Pr; 1995;
  2. Adelson PD, Kochanek PM. Head injury in children. J Child Neurol. 1998;13:2–15
  3. Kaufmann PM, Fletcher JM, Levin HS, Miner ME, Ewing-Cobbs L. Attentional disturbance after pediatric closed head injury. J Child Neurol. 1993;8:348–353
  4. Catroppa C, Anderson V. Attentional skills in the acute phase following pediatric traumatic brain injury. Child Neuropsychol. 1999;5:251–264
  5. Ewing-Cobbs L, Prasad MR, Fletcher JM, Levin HS, Miner ME, Eisenberg HM. Attention after pediatric traumatic brain injury: a multidimensional assessment. Child Neuropsychol. 1998;4:35–48
  6. Vriezen E, Pigott S. Sensitivity of measures of attention to pediatric brain injury. Brain Cogn. 2000;44:67–82
  7. Ward H, Shum D, Wallace G, Boon J. Pediatric traumatic brain injury and procedural memory. J Clin Exp Neuropsychol. 2002;24:458–470
  8. Tong KA, Ashwal S, Holshouser BA, et al. Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology. 2003;227:332–339
  9. Bradley WG. MR appearance of hemorrhage in the brain. Radiology. 1993;189:15–26
  10. Blackman JA, Rice SA, Matsumoto JA, et al. Brain imaging as a predictor of early functional outcome following traumatic brain injury in children, adolescents, and young adults. J Head Trauma Rehabil. 2003;18:493–503
  11. Meythaler JM, Peduzzi JD, Eleftheriou E, Novack TA. Current concepts: diffuse axonal injury-associated traumatic brain injury. Arch Phys Med Rehabil. 2001;82:1461–1471
  12. Graham DI, McIntosh TK, Maxwell WL, Nicoll JA. Recent advances in neurotrauma. J Neuropathol Exp Neurol. 2000;59:641–651
  13. Gorrie C, Oakes S, Duflou J, Blumbergs P, Waite PM. Axonal injury in children after motor vehicle crashes: extent, distribution, and size of axonal swellings using beta-APP immunohistochemistry. J Neurotrauma. 2002;19:1171–1182
  14. Orrison WW, Gentry LR, Stimac GK, Tarrel RM, Espinosa MC, Cobb LC. Blinded comparison of cranial CT and MR in closed head injury evaluation. AJNR Am J Neuroradiol. 1994;15:351–356
  15. Levin HS, Mendelsohn D, Lilly MA, et al. Magnetic resonance imaging in relation to functional outcome of pediatric closed head injury: a test of the Ommaya-Gennarelli model. Neurosurgery. 1997;40:432–440
  16. Levin HS, Amparo E, Eisenberg HM, et al. Magnetic resonance imaging and computerized tomography in relation to the neurobehavioral sequelae of mild and moderate head injuries. J Neurosurg. 1987;66:706–713
  17. Chiaretti A, Visocchi M, Viola L, et al. Diffuse axonal lesions in childhood. Pediatr Med Chir. 1998;20:393–397
  18. Vowles GH, Scholtz CL, Cameron JM. Diffuse axonal injury in early infancy. J Clin Pathol. 1987;40:185–189
  19. Kurihara M, Kumagai K, Nakae Y. Functional outcome after diffuse axonal injury in childhood traumatic brain injury. No To Hattatsu. 1999;31:408–414
  20. Gleckman AM, Bell MD, Evans RJ, Smith TW. Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med. 1999;123:146–151
  21. Tong KA, Ashwal S, Holshouser BA, et al. Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions. Ann Neurol. 2004;56:36–50
  22. Grados MA, Slomine BS, Gerring JP, Vasa R, Bryan N, Denckla MB. Depth of lesion model in children and adolescents with moderate to severe traumatic brain injury: use of SPGR MRI to predict severity and outcome. J Neurol Neurosurg Psychiatry. 2001;70:350–358
  23. Yanagawa Y, Tsushima Y, Tokumaru A, et al. A quantitative analysis of head injury using T2*-weighted gradient-echo imaging. J Trauma. 2000;49:272–277
  24. Scheid R, Preul C, Gruber O, Wiggins C, von Cramon DY. Diffuse axonal injury associated with chronic traumatic brain injury: evidence from T2*-weighted gradient-echo imaging at 3 T. AJNR Am J Neuroradiol. 2003;24:1049–1056
  25. Scheid R, Walther K, Guthke T, Preul C, von Cramon . Cognitive sequelae of diffuse axonal injury. Arch Neurol. 2006;63:418–424
  26. Reichenbach JR, Venkatesan R, Schillinger DJ, Kido DK, Haacke EM. Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology. 1997;204:272–277
  27. Fiser DH, Long N, Roverson P, Hefley G, Zolten K, Brodie-Fowler M. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessment. Crit Care Med. 2000;28:216–220
  28. Babikian T, Freier MC, Tong KA, et al. Susceptibility weighted imaging: neuropsychological outcome and pediatric head injury. Pediatr Neurol. 2005;33:179–189
  29. Babikian T, Freier MC, Ashwal S, Riggs ML, Burley T, Holshouser BA. MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI. J Magn Reson Imaging. 2006;24:801–811
  30. Danielsen ER, Ross B. In: Magnetic resonance spectroscopy diagnosis of neurological diseases. New York: Marcel Dekker; 1999;p. 349
  31. Garnett MR, Corkill RG, Blamire AM, et al. Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study. J Neurotrauma. 2001;18:231–240
  32. Alessandri B, Doppenberg E, Zauner A, Woodward J, Choi S, Bullock R. Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study. Acta Neurochir Suppl (Wien). 1999;75:25–28
  33. Bullock R, Zauner A, Woodward JJ, et al. Factors affecting excitatory amino acid release following severe head injury. J Neurosurg. 1998;89:507–518
  34. Garnett MR, Blamire AM, Corkill RG, Cadoux-Hudson TA, Rajagopalan B, Stylet P. Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury. Brain. 2000;123:2046–2054
  35. Danielsen ER, Michaelis T, Ross BD. Three methods of calibration in quantitative proton MR spectroscopy. J Magn Reson B. 1995;106:287–291
  36. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679
  37. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized NMR spectroscopy in different regions of the human brain in vivo: relaxation times and concentration of cerebral metabolites. Magn Reson Med. 1989;11:47–63
  38. Kreis R, Ernst T, Ross BD. Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Res Med. 1993;30:424–437
  39. Kreis R, Hofmann L, Kuhlmann B, Boesch C, Bossi E, Huppi PS. Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy. Magn Reson Med. 2002;48:949–958
  40. Holshouser BA, Ashwal S, Luh GY, et al. Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology. 1997;202:487–496
  41. Pouwels PJ, Brockmann K, Kruise B, et al. Regional age-dependence of human brain metabolites form infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res. 1999;46:474–485
  42. Horska A, Kaufmann W, Brant LJ, Naidu S, Harris JC, Barker PB. In vivo quantitative proton MRSI study of brain development from childhood to adolescence. J Magn Reson Imaging. 2002;15:137–143
  43. Ashwal S, Holshouser BA, Shu SK, et al. Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury. Pediatr Neurol. 2000;23:114–125
  44. Brenner T, Freier MC, Holshouser BA, Burley T, Ashwal S. Predicting neuropsychologic outcome after traumatic brain injury in children. Pediatr Neurol. 2003;28:104–114
  45. Ross BD, Ernst T, Kreis R, et al. 1H MRS in acute traumatic brain injury. J Magn Reson Imaging. 1998;8:829–840
  46. Cecil KM, Hills EC, Sandel ME, et al. Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. J Neurosurg. 1998;88:795–801
  47. Sinson G, Bagley LJ, Cecil KM, et al. Magnetization transfer imaging and proton MR spectroscopy in the evaluation of axonal injury: correlation with clinical outcome after traumatic brain injury. AJNR Am J Neuroradiol. 2001;22:143–151
  48. Ashwal S, Holshouser B, Tong K, et al. Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatr Res. 2004;56:630–638
  49. Ashwal S, Holshouser BA, Tong K, et al. Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. J Neurotrauma. 2004;21:1539–1552
  50. Friedman SD, Brooks WM, Jung RE, et al. Quantitative proton MRS predicts outcome after traumatic brain injury. Neurology. 1999;52:1384–1391
  51. Friedman SD, Brooks WM, Jung RE, Hart BL, Yeo RA. Spectroscopic findings correspond to neuropsychological function in traumatic brain injury. AJNR Am J Neuroradiol. 1998;19:1879–1885
  52. Brooks WM, Stidley CA, Petropoulos H, et al. Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study. J Neurotrauma. 2000;17:629–640
  53. Parry L, Shores A, Rae C, et al. An investigation of neuronal integrity in severe paediatric traumatic brain injury. Child Neuropsychol. 2004;10:248–261
  54. Macmillan CS, Wild JM, Wardlaw JM, Andrews PJ, Marshall I, Easton VJ. Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be “ischaemic.” (A primary study and review of the literature). Acta Neurochir (Wien). 2002;144:853–862discussion 862
  55. Signoretti S, Marmarou A, Fatouros P, et al. Application of chemical shift imaging for measurement of NAA in head injured patients. Acta Neurochir Suppl. 2002;81:373–375
  56. Govindaraju V, Gauger GE, Manley GT, Ebel A, Meeker M, Maudsley AA. Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol. 2004;25:730–737
  57. Hunter JV, Thornton RJ, Wang ZJ, et al. Late proton MR spectroscopy in children after traumatic brain injury: correlation with cognitive outcomes. AJNR Am J Neuroradiol. 2005;26:482–488
  58. Holshouser BA, Ashwal S, Tong KA. Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury. AJNR Am J Neuroradiol. 2005;26:1276–1285
  59. Shutter LA, Tong K, Holshouser B. Proton MRS in acute traumatic brain injury: role of glutamate/glutamine for outcome. J Neurotrauma. 2004;21:1693–1705

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)01280-9

doi: 10.1016/j.apmr.2006.07.275

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12, Supplement , Pages 50-58 , December 2006