Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12, Supplement , Pages 43-49 , December 2006

Rehabilitation of Unilateral Spatial Neglect: New Insights From Magnetic Resonance Perfusion Imaging

  • Argye E. Hillis, MD

      Affiliations

    • Corresponding Author InformationReprint requests to Argye E. Hillis, MD, MA, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Phipps 126, 600 N Wolfe St, Baltimore, MD 21287

References 

  1. Vallar G, Bottini G, Paulesu E. Neglect syndromes: the role of the parietal cortex. Adv Neurol. 2003;93:293–319
  2. Tegner R, Levander M. Through a looking glass: a new technique to demonstrate directional hypokinesia in unilateral neglect. Brain. 1991;114:1943–1951
  3. Bisiach E, Geminiani G, Berti A, Rusconi ML. Perceptual and premotor factors of unilateral neglect. Neurology. 1990;40:1278–1281
  4. Nico D. Detecting directional hypokinesia: the epidiascope technique. Neuropsychologia. 1996;34:471–474
  5. Coslett HB, Bowers D, Fitzpatrick E, Haws B, Heilman KM. Directional hypokinesia and hemispatial inattention in neglect. Brain. 1990;113:475–486
  6. Na DL, Adair JC, Williamson DJ, Schwartz RL, Haws B, Heilman KM. Dissociation of sensory-attentional from motor-intentional neglect. J Neurol Neurosurg Psychiatry. 1998;64:331–338
  7. Hillis AE, Caramazza A. A framework for interpreting distinct patterns of hemispatial neglect. Neurocase. 1995;1:189–207
  8. Chatterjee A. Picturing unilateral spatial neglect: viewer versus object centered reference frames. J Neurol Neurosurg Psychiatry. 1994;57:1236–1240
  9. Behrmann M, Geng J. What’s left when all is said and done? Spatial coding and hemispatial neglect. In:  Karnath HO,  Milner D,  Vallar G editor. The cognitive and neural bases of spatial neglect. New York: Oxford Univ Pr; 2002;p. 85–100
  10. Mennemeier M, Chatterjee A, Heilman K. A comparison of the influences of body and environment centered reference frames on neglect. Brain. 1994;117:1013–1021
  11. Humphreys GW, Riddoch MJ. Separate coding of space within and between perceptual objects: evidence from unilateral visual neglect. Cogn Neuropsychol. 1995;12:283–311
  12. Ota H, Fujii T, Suzuki K, Fukatsu R, Yamadori A. Dissociation of body-centered and stimulus-centered representations in unilateral neglect. Neurology. 2001;57:2064–2069
  13. Marsh EB, Hillis AE. Dissociation between egocentric and allocentric visuospatial and tactile neglect in acute stroke. Cortex. In press.
  14. Hillis AE, Newhart M, Heidler J, Barker PB, Degaonkar M. Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. J Neurosci. 2005;25:3161–3167
  15. Kleinman JT, Newhart M, Davis C, Heidler-Gary J, Gottesman RF, Hillis AE. Right hemispatial neglect: frequency and characterization following acute left hemisphere stroke. Brain Cogn. In press.
  16. McGlinchey-Berroth R, Bullis DP, Milberg WP, Verfaellie M, Alexander M, D’Esposito M. Assessment of neglect reveals dissociable behavioral but not neuroanatomical subtypes. J Int Neuropsychol Soc. 1996;2:441–451
  17. Barber PA, Darby DG, Desmond PM, et al. Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI. Neurology. 1998;51:418–426
  18. Beaulieu C, de Crespigny A, Tong DC, Moseley ME, Albers GW, Marks MP. Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome. Ann Neurol. 1999;46:568–578
  19. Hillis AE, Barker P, Beauchamp N, Gordon B, Wityk R. MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect. Neurology. 2000;55:782–788
  20. Hillis AE, Ulatowski JA, Barker P, Wityk RJ. A simple test of hemispatial neglect reflects change in tissue perfusion with intervention in acute nondominant hemisphere stroke. Stroke. 2003;34:79–80
  21. Hillis AE, Wityk RJ, Barker PB, et al. Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion. Brain. 2002;125(Pt 5):1094–1104
  22. Karnath HO, Zopf R, Johannsen L, Berger MF, Nagele T, Klose U. Normalized perfusion MRI to identify common areas of dysfunction: patients with basal ganglia neglect. Brain. 2005;128:2462–2469
  23. Hillis AE, Newhart M, Heidler J, Marsh EB, Barker PB, Dagaonkar M. The neglected role of the right hemisphere in spatial representation of words for reading. Aphasiology. 2005;19:225–238
  24. Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nature Rev Neurosci. 2002;3:201–215
  25. Shulman GL, Ollinger JM, Linenweber M, Petersen SE, Corbetta M. Multiple neural correlates of detection in the human brain. Proc Natl Acad Sci U S A. 2001;98:313–318
  26. Redding GM, Wallace B. Prism adaptation and unilateral neglect: review and analysis. Neuropsychologia. 2006;44:1–20
  27. Frassinetti F, Angeli V, Meneghello F, Avanzi S, Ladavas E. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–623
  28. Mattingley JB. Visuomotor adaptation to optical prisms: a new cure for spatial neglect?. Cortex. 2002;38:277–283
  29. Rode G, Pisella L, Rossetti Y, Farne A, Boisson D. Bottom-up transfer of sensory-motor plasticity to recovery of spatial cognition: visuomotor adaptation and spatial neglect. Prog Brain Res. 2003;142:273–287
  30. Rossetti Y, Rode G, Pisella L, et al. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature. 1998;395:166–169
  31. McIntosh RD, Rossetti Y, Milner AD. Prism adaptation improves chronic visual and haptic neglect: a single case study. Cortex. 2002;38:309–320
  32. Rubens AB. Caloric stimulation and unilateral visual neglect. Neurology. 1985;35:1019–1024
  33. Cappa S, Sterzi R, Vallar G, Bisiach E. Remission of hemineglect and anosognosia during vestibular stimulation. Neuropsychologia. 1987;25:775–782
  34. Adair JC, Na DL, Schwartz RL, Heilman KM. Caloric stimulation in neglect: evaluation of response as a function of neglect type. J Int Neuropsychol Soc. 2003;9:983–988
  35. Geminiani G, Bottini G. Mental representation and temporary recovery from unilateral neglect after vestibular stimulation. J Neurol Neurosurg Psychiatry. 1992;55:332–333
  36. Karnath HO, Himmelbach M, Perenin MT. Neglect-like behavior in healthy subjects: dissociation of space exploration and goal-directed pointing after vestibular stimulation. Exp Brain Res. 2003;153:231–238
  37. Kinsbourne M. Hemi-neglect and hemisphere rivalry. Adv Neurol. 1977;18:41–49
  38. Oliveri M, Bisiach E, Brighina F, et al. rTMS of the unaffected hemisphere transiently reduces contralesional visuospatial hemineglect. Neurology. 2001;57:1338–1340
  39. Brighina F, Bisiach E, Oliveri M, et al. 1 Hz repetitive transcranial magnetic stimulation of the unaffected hemisphere ameliorates contralesional visuospatial neglect in humans. Neurosci Lett. 2003;336:131–133
  40. Johannsen L, Ackermann H, Karnath HO. Lasting amelioration of spatial neglect by treatment with neck muscle vibration even without concurrent training. J Rehabil Med. 2003;35:249–253
  41. Schindler I, Kerkhoff G, Karnath HO, Keller I, Goldenberg G. Neck muscle vibration induces lasting recovery in spatial neglect. J Neurol Neurosurg Psychiatry. 2002;73:412–419
  42. Bottini G, Karnath HO, Vallar G, et al. Cerebral representations for egocentric space: functional-anatomical evidence from caloric vestibular stimulation and neck vibration. Brain. 2001;124:1182–1196
  43. Malhotra P, Parton A, Husain M. Noradrenergic modulation of space exploration in visual neglect. Ann Neurol. 2006;59:186–190
  44. Pierce SR, Buxbaum LJ. Treatments of unilateral neglect: a review. Arch Phys Med Rehabil. 2002;83:256–268
  45. Ferber S, Danckert J, Joanisse M, Goltz HC, Goodale MA. Eye movements tell only half the story. Neurology. 2003;60:1826–1829
  46. Myers P. Right hemisphere damage: disorders of communication and cognition. San Diego: Singular; 1999;
  47. Hillis AE, Mordkoff T, Caramazza A. Mechanisms of spatial attention revealed by hemispatial neglect. Cortex. 1999;35:433–442
  48. Hillis AE, Selnes O. Cases of aphasia or neglect due to Creutzfeldt-Jakob disease. Aphasiology. 1999;13:743–754
  49. Hillis AE, Wityk RJ, Barker PB, Ulatowski JA, Jacobs MA. Change in perfusion in acute nondominant hemisphere stroke may be better estimated by tests of hemispatial neglect than by the NIHSS. Stroke. 2003;34:2392–2398
  50. Hillis AE, Ulatowski JA, Barker PB, et al. A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute stroke. Cerebrovasc Dis. 2003;16:236–246
  51. Baron JC, Marchal G. Functional imaging in vascular disorders. In:  Mazziotta JC,  Toga AW,  Frackowiak RS editor. Brain mapping: the disorders. San Diego: Academic Pr; 2000;p. 299–311

 Supported by the National Institutes of Health (grant no. R01 NS047691).

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)01278-0

doi: 10.1016/j.apmr.2006.08.331

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 12, Supplement , Pages 43-49 , December 2006

Article Tools

* Image Usage & Resolution