Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 11 , Pages 1459-1462, November 2006

Bone Mineral Density in Hip-Fracture Patients With Parkinson’s Disease: A Case-Control Study

  • Marco Di Monaco, MD

      Affiliations

    • Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy
    • Corresponding Author InformationReprint requests to Marco Di Monaco, MD, Osteoporosis Research Center, Presidio Sanitario San Camillo, Strada Santa Margherita 136, 10131, Torino, Italy
  • ,
  • Fulvia Vallero, MD

      Affiliations

    • Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy
  • ,
  • Roberto Di Monaco, PhD

      Affiliations

    • Institute of Social and Economical Research, Società Ricerca e Formazione, Torino, Italy.
  • ,
  • Rosa Tappero, MD

      Affiliations

    • Division of Physical Medicine and Rehabilitation, Presidio Sanitario San Camillo, Torino, Italy
  • ,
  • Alberto Cavanna, MD

      Affiliations

    • Osteoporosis Research Center, Presidio Sanitario San Camillo, Torino, Italy

Abstract 

Di Monaco M, Vallero F, Di Monaco R, Tappero R, Cavanna A. Bone mineral density in hip-fracture patients with Parkinson’s disease: a case-control study.

Objective

To investigate bone mineral density (BMD) levels in patients with Parkinson’s disease (PD) who sustained a hip fracture.

Design

Case-control study.

Setting

Rehabilitation hospital in Italy.

Participants

We investigated 831 out of 887 white patients consecutively admitted to a rehabilitation hospital because of an original hip fracture resulting from a fall. Twenty-eight (3.37%) of the 831 patients were affected by PD. Twenty-eight controls matched for sex, age, and hip-fracture type (cervical or trochanteric) were found among the 803 non-PD patients.

Interventions

Not applicable.

Main Outcome Measures

BMD was assessed by dual-energy x-ray absorptiometry (DXA) at the unfractured femur. Five sites were investigated in each subject: total proximal femur, femoral neck, trochanter, intertrochanteric area, and Ward’s triangle. DXA scan was performed a mean ± standard deviation of 22.2±7.8 days after fracture occurrence in the 28 patients and 22.0±5.3 days after fracture occurrence in the 28 controls.

Results

BMD expressed as a T score did not differ significantly between the 28 PD patients and the 28 controls, whereas z score in the PD patients was significantly lower than 0±1 in the age- and sex-matched general population at 4 of the 5 sites of BMD assessment.

Conclusions

A sample of PD fallers who sustained a hip fracture had femoral BMD levels similar to those found in matched hip-fracture fallers who did not suffer from PD and significantly lower than those found in the matched reference population.

Key Words: Bone mineral density, Hip fracture, Osteoporosis, Parkinson’s disease, Rehabilitation

 

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)00870-7

doi:10.1016/j.apmr.2006.07.265

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 11 , Pages 1459-1462, November 2006