Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 10 , Pages 1327-1333 , October 2006

Determinants of Forced Expiratory Volume in 1 Second (FEV1), Forced Vital Capacity (FVC), and FEV1/FVC in Chronic Spinal Cord Injury

Presented to the American Paraplegia Society, September 7−9, 2004, Las Vegas, NV.

  • Nitin B. Jain, MD, MSPH

      Affiliations

    • Research Service, Physical Medicine and Rehabilitation Medicine Service, and Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, MA
    • Channing Laboratory, Brigham and Women’s Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
  • ,
  • Robert Brown, MD

      Affiliations

    • Pulmonary and Critical Care Medicine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
  • ,
  • Carlos G. Tun, MD

      Affiliations

    • Research Service, Physical Medicine and Rehabilitation Medicine Service, and Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, MA
    • Harvard Medical School, Boston, MA
  • ,
  • David Gagnon, MD, MPH, PhD

      Affiliations

    • Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston University School of Public Health, Boston, MA
  • ,
  • Eric Garshick, MD, MOH

      Affiliations

    • Research Service, Physical Medicine and Rehabilitation Medicine Service, and Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, MA
    • Channing Laboratory, Brigham and Women’s Hospital, Boston, MA
    • Harvard Medical School, Boston, MA
    • Corresponding Author InformationReprint requests to Eric Garshick, MD, MOH, Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, 1400 VFW Pkwy, West Roxbury, MA 02132

References 

  1. DeVivo MJ, Stover SL. Long term survival and causes of death. In:  Stover SL,  DeLisa JA,  Whiteneck GG editor. Spinal cord injury: clinical outcomes from the model systems. Gaithersburg: Aspen; 1995;p. 289–316
  2. DeVivo MJ, Black KJ, Stover SL. Causes of death during the first 12 years after spinal cord injury. Arch Phys Med Rehabil. 1993;74:248–254
  3. Garshick E, Kelley A, Cohen SA, et al. A prospective assessment of mortality in chronic spinal cord injury. Spinal Cord. 2005;43:408–416
  4. Fugl-Meyer AR. Effects of respiratory muscle paralysis in tetraplegic and paraplegic patients. Scand J Rehabil Med. 1971;3:141–150
  5. Fugl-Meyer AR, Grimby G. Ventilatory function in tetraplegic patients. Scand J Rehabil Med. 1971;3:151–160
  6. Kokkola K, Moller K, Lehtonen T. Pulmonary function in tetraplegic and paraplegic patients. Ann Clin Res. 1975;7:76–79
  7. Ohry A, Molho M, Rozin R. Alterations of pulmonary function in spinal cord injured patients. Paraplegia. 1975;13:101–108
  8. Almenoff PL, Spungen AM, Lesser M, Bauman WA. Pulmonary function survey in spinal cord injury: influences of smoking and level and completeness of injury. Lung. 1995;173:297–306
  9. Linn WS, Adkins RH, Gong H, Waters RL. Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 southern California adult outpatients. Arch Phys Med Rehabil. 2000;81:757–763
  10. Linn WS, Spungen AM, Gong H, Adkins RH, Bauman WA, Waters RL. Forced vital capacity in two large outpatient populations with chronic spinal cord injury. Spinal Cord. 2001;39:263–268
  11. Linn WS, Spungen AM, Gong H, Bauman WA, Adkins RH, Waters RL. Smoking and obstructive lung dysfunction in persons with chronic spinal cord injury. J Spinal Cord Med. 2003;26:28–35
  12. Spungen AM, Grimm DR, Schilero G, et al. Relationship of respiratory symptoms with smoking status and pulmonary function in chronic spinal cord injury. J Spinal Cord Med. 2002;25:23–27
  13. Huldtgren AC, Fugl-Meyer AR, Jonasson E, Bake B. Ventilatory dysfunction and respiratory rehabilitation in post-traumatic quadriplegia. Eur J Respir Dis. 1980;61:347–356
  14. Ditunno JF, Young W, Donovan WH, Creasey G. The international standards booklet for neurological and functional classification of spinal cord injury (American Spinal Injury Association). Paraplegia. 1994;32:70–80
  15. Garshick E, Ashba J, Tun CG, Lieberman SL, Brown R. Assessment of stature in spinal cord injury. J Spinal Cord Med. 1997;20:36–42
  16. Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis. 1978;118(6 Pt 2):1–120
  17. American Thoracic Society. Standardization of Spirometry, 1994 Update. Am J Respir Crit Care Med. 1995;152:1107–1136
  18. Ashba J, Garshick E, Tun CG, et al. Spirometry—acceptability and reproducibility in spinal cord injured subjects. J Am Paraplegia Soc. 1993;16:197–203
  19. Kelley A, Garshick E, Gross ER, Lieberman SL, Tun CG, Brown R. Spirometry testing standards in spinal cord injury. Chest. 2003;123:725–730
  20. Tully K, Koke K, Garshick E, Lieberman SL, Tun CG, Brown R. Maximal expiratory pressures in spinal cord injury using two mouthpieces. Chest. 1997;112:113–116
  21. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  22. Crapo RO, Morris AH, Clayton PD, Nixon CR. Lung volumes in healthy nonsmoking adults. Bull Eur Physiopathol Respir. 1982;18:419–425
  23. Dockery DW, Ware JH, Ferris BG, et al. Distribution of forced expiratory volume in one second and forced vital capacity in healthy, white, adult never-smokers in six U.S. cities. Am Rev Respir Dis. 1985;131:511–520
  24. Forner JV. Lung volumes and mechanics of breathing in tetraplegics. Paraplegia. 1980;18:258–266
  25. Haas F, Axen K, Pineda H, Gandino D, Haas A. Temporal pulmonary function changes in cervical cord injury. Arch Phys Med Rehabil. 1985;66:139–144
  26. Dicpinigaitis PV, Spungen AM, Bauman WA, Absgarten A, Almenoff PL. Bronchial hyperresponsiveness after cervical spinal cord injury. Chest. 1994;105:1073–1076
  27. Almenoff PL, Alexander LR, Spungen AM, Lesser MD, Bauman WA. Bronchodilatory effects of ipratropium bromide in patients with tetraplegia. Paraplegia. 1995;33:274–277
  28. Affonce D, Brown R, Fredberg JJ, Garshick E, Lutchen KR. Does ability to maximally dilate airways relate to airway tone and inspiratory capacity in subjects with hyperreactivity [abstract]. Am J Respir Crit Care Med. 2004;169:A248
  29. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis. 1981;123:659–664
  30. Knudson RJ, Lebowitz MD, Holberg CJ, Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983;127:725–734
  31. Enright PL, Kronmal RA, Higgins MW, Schenker MB, Haponik EF. Prevalence and correlates of respiratory symptoms and disease in the elderly (Cardiovascular Health Study). Chest. 1994;106:827–834
  32. Jaakkola MS, Jaakkola JJ, Ernst P, Becklake MR. Respiratory symptoms in young adults should not be overlooked. Am Rev Respir Dis. 1993;147:359–366
  33. Enright PL, McClelland RL, Newman AB, Gottlieb DJ, Lebowitz MD Cardiovascular Health Study Research Group. Underdiagnosis and undertreatment of asthma in the elderly. Chest. 1999;116:603–613
  34. Litonjua AA, Sparrow D, Celedon JC, DeMolles D, Weiss ST. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax. 2002;57:581–585
  35. Lazarus R, Sparrow D, Weiss ST. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest. 1997;111:891–898
  36. Sue DY. Obesity and pulmonary function: more or less?. Chest. 1997;111:844–845
  37. Pistelli F, Bottai M, Viegi G, et al. Smooth reference equations for slow vital capacity and flow-volume curve indexes. Am J Respir Crit Care Med. 2000;161(3 Pt 1):899–905
  38. Estenne M, Heilporn A, Delhez L, Yernault JC, De Troyer A. Chest wall stiffness in patients with chronic respiratory muscle weakness. Am Rev Respir Dis. 1983;128:1002–1007
  39. Scanlon PD, Loring SH, Pichurko BM, et al. Respiratory mechanics in acute quadriplegia (Lung and chest wall compliance and dimensional changes during respiratory maneuvers). Am Rev Respir Dis. 1989;139:615–620
  40. Villanueva EV. The validity of self-reported weight in US adults: a population based cross-sectional study. BMC Public Health. 2001;1:11
  41. Liaw MY, Lin MC, Cheng PT, Wong MK, Tang FT. Resistive inspiratory muscle training: its effectiveness in patients with acute complete cervical cord injury. Arch Phys Med Rehabil. 2000;81:752–756

 Supported by National Institute of Child Health and Human Development, National Institutes of Health (grant no. RO1 HD42141), the Massachusetts Veterans Epidemiology Research and Information Center, Cooperative Studies Program, and Health Services Research and Development, Department of Veterans Affairs.No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)00685-X

doi: 10.1016/j.apmr.2006.06.015

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 10 , Pages 1327-1333 , October 2006