Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 7 , Pages 909-913 , July 2006

Side Effects and Adverse Events Related to Intraligamentous Injection of Sclerosing Solutions (Prolotherapy) for Back and Neck Pain: A Survey of Practitioners

  • Simon Dagenais, DC, PhD

      Affiliations

    • Department of Pediatrics, University of Ottawa, ON, Canada
    • Chalmers Research Group, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada
    • CAM Research Institute, Irvine, CA
    • Corresponding Author InformationReprint requests to Simon Dagenais, DC, PhD, CAM Research Institute, 27 Peters Canyon Rd, Irvine, CA 92606
    • ,
  • Oladele Ogunseitan, MPH, PhD

      Affiliations

    • Department of Environmental Health, Science, and Policy, University of California, Irvine, CA
    • ,
  • Scott Haldeman, DC, MD, PhD

      Affiliations

    • Department of Neurology, University of California, Irvine, CA
    • Department of Epidemiology, University of California, Los Angeles, CA
    • Research Division, Southern California University of Health Sciences, Whittier, CA
    • ,
  • James R. Wooley, DC

      Affiliations

    • CAM Research Institute, Irvine, CA
    • ,
  • Robert L. Newcomb, PhD

      Affiliations

    • Statistical Consulting Center, University of California, Irvine, CA.

References 

  1. Wolsko P , Eisenberg DM , Davis RB , Kessler R , Phillips RS . Patterns and perceptions of care for treatment of back and neck pain (results of a national survey) . Spine . 2003;28:292–297 discussion 298
  2. Dagenais S , Haldeman S , Wooley J . Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain (a critical review of the literature) . Spine J . 2005;5:310–328
  3. Banks A . A rationale for prolotherapy . J Orthop Med . 1991;13:54–59
  4. Quality Care Review Commission California Medical Association . Multiple injections of sclerosant solution . West J Med . 1985;142:841
  5. US Food and Drug Administration . What is a serious adverse event? . 2004; January 23, Available at: http://www.fda.gov/medwatch/report/DESK/advevnt.htm. Accessed May 9, 2005.
  6. Schneider R , Williams JJ , Liss L . Fatality after injection of sclerosing agent to precipitate fibro-osseous proliferation . JAMA . 1959;170:1768–1772
  7. Yelland M , Glasziou P , Bogduk N , Schluter P , McKernon M . Prolotherapy injections, saline injections, and exercises for chronic low-back pain (a randomized trial) . Spine . 2004;29:9–16
  8. Bogduk N . Management of chronic low back pain . Med J Aust . 2004;180:79–83
  9. Fitzgibbon D , Posner KL , Domino KB , Caplan RA , Lee LA , Cheny FW  American Society of Anesthesiologists . Chronic pain management (American Society of Anesthesiologists Closed Claims Project) . Anesthesiology . 2004;100:98–105
  10. Huston C , Slipman C , Garvin C . Complications and side effects of cervical and lumbosacral selective nerve root injections . Arch Phys Med Rehabil . 2005;86:277–283
  11. Lee L . Injuries associated with regional anesthesia in the 1980s and 1990s (a closed claims analysis) . Anesthesiology . 2004;101:143–152
  12. Nelemans P , deBie R , deVet H , Sturmans F . Injection therapy for subacute and chronic benign low back pain . Spine . 2001;26:501–505
  13. AHFS drug information . Bethesda: American Society of Health System Pharmacists; 2003;
  14. In:  Sweetman SC editors. Martindale (the complete drug reference) . 33rd ed.. London: Pharmaceutical Pr; 2002;
  15. In:  Gennaro AR editors. Remington (the science and practice of pharmacy) . 20th ed.. Easton: Lippincott Williams & Wilkins; 2000;
  16. Ongley M , Klein R , Dorman T , Eek B , Hubert L . A new approach to the treatment of chronic low back pain . Lancet . 1987;2:143–146
  17. Dorman TA . Prolotherapy (a survey) . J Orthop Med . 1993;15:49–50

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)00323-6

doi: 10.1016/j.apmr.2006.03.017

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 7 , Pages 909-913 , July 2006

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