Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 7 , Pages 904-908 , July 2006

Vitamin D Deficiency and Osteoporosis in Rehabilitation Inpatients

Presented to the American Academy of Physical Medicine and Rehabilitation, October 28, 2005, Philadelphia, PA.

  • Leonid M. Shinchuk, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Boston University Medical Center, Boston, MA.
    • ,
  • Leslie Morse, DO

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Boston University Medical Center, Boston, MA.
    • ,
  • Nadia Huancahuari

      Affiliations

    • Department of Medicine, Boston University Medical Center, Boston, MA.
    • ,
  • Seth Arum, MD

      Affiliations

    • Department of Medicine, Boston University Medical Center, Boston, MA.
    • ,
  • Tai C. Chen, PhD

      Affiliations

    • Department of Medicine, Boston University Medical Center, Boston, MA.
    • ,
  • Michael F. Holick, MD, PhD

      Affiliations

    • Department of Medicine, Boston University Medical Center, Boston, MA.
    • Corresponding Author InformationCorrespondence to Michael F. Holick, MD, PhD, Boston University School of Medicine, 715 Albany St, #M1013, Boston, MA 02118.

References 

  1. Holick MF . Vitamin D (photobiology, metabolism, mechanism of action, and clinical applications) . In:  Favus MJ editors. Primer on the metabolic bone diseases and disorders of mineral metabolism . 5th ed.. Philadelphia: Lippincott; 1999;p. 92–98
  2. Kinyamu HK , Gallagher JC , Balhorn KE , Petranick KM , Rafferty KA . Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes . Am J Clin Nutr . 1997;65:790–797
  3. Aaron JE , Gallagher JC , Anderson J , et al.   Frequency of osteomalacia and osteoporosis in fracture of the proximal femur . Lancet . 1974;1:229–233
  4. Holick MF . Vitamin D (a millenium perspective) . J Cell Biochem . 2003;1(88):296–307
  5. Simpson RU , Thomas GA , Arnold AJ . Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle . J Biol Chem . 1985;260:8882–8891
  6. Costa EM , Blau HM , Feldman D . 1,25-dihydroxyvitamin D3 receptors and hormonal responses in cloned human skeletal muscle cells . Endocrinology . 1986;119:2214–2220
  7. Haddad JG , Walgate J , Min C , Hahn TJ . Vitamin D metabolite-binding proteins in human tissue . Biochim Biophys Acta . 1976;22(444):921–925
  8. Bischoff HA , Borchers M , Gudat F , et al.   In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue . Histochem J . 2001;33:19–24
  9. Mowe M , Haug E , Bohmer T . Low serum calcidiol concentration in older adults with reduced muscular function . J Am Geriatr Soc . 1999;47:220–226
  10. Dhesi JK , Bearne LM , Moniz C , et al.   Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status . J Bone Miner Res . 2002;17:891–897
  11. Venning G . Recent developments in vitamin D deficiency and muscle weakness among elderly people . BMJ . 2005;330:524–526
  12. Holick MF , MacLaughlin JA , Clark MB , et al.   Photosynthesis of previtamin D3 in human skin and the physiologic consequences . Science . 1980;210:203–205
  13. MacLaughlin JA , Anderson RR , Holick MF . Spectral character of sunlight modulates photosynthesis of previtamin D3 and its photoisomers in human skin . Science . 1982;216:1001–1003
  14. Holick MF . Sunlight and vitamin D for bone health and prevention of autoimmune disease, cancers, and cardiovascular disease . Am J Clin Nutr . 2004;80(6 Suppl):1678S–1688S
  15. Thomas MK , Lloyd-Jones DM , Thadhani RI , et al.   Hypovitaminosis D in medical inpatients . N Engl J Med . 1998;338:777–783
  16. Gloth FM , Tobin JD . Vitamin D deficiency in older people . J Am Geriatr Soc . 1995;43:822–828
  17. Siris ES , Miller PD , Barrett-Connor E , et al.   Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women (results from the National Osteoporosis Risk Assessment) . JAMA . 2001;286:2815–2822
  18. Siddiqui NA , Shetty KR , Duthie EH . Osteoporosis in older men (discovering when and how to treat it) . Geriatrics . 1999;54(9):20–22 27-8, 30
  19. Ray NF , Chan JK , Thamer M , Melton LJ . Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995 (report from the National Osteoporosis Foundation) . J Bone Miner Res . 1997;12:24–35
  20. Shinchuk LM , Huancahuari N , Ingersoll D , Holick MF . Vitamin D deficiency and osteoporosis (highly prevalent in men and women admitted to subacute rehabilitation facility in Boston, Massachusetts during summer) . [abstract] Am J Phys Med Rehabil . 2005;84:203
  21. Bischoff-Ferrari HA , Dietrich T , Orav EJ , Dawson-Hughes B . Positive association between 25-hydroxy vitamin D levels and bone mineral density (a population-based study of younger and older adults) . Am J Med . 2004;116:634–639
  22. Janssen HC , Samson MM , Verhaar HJ . Vitamin D deficiency, muscle function, and falls in elderly people . Am J Clin Nutr . 2002;75:611–615
  23. Pfeifer M , Begerow B , Minne HW , et al.   Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis . Exp Clin Endocrinol Diabetes . 2001;109:87–92
  24. Sato Y , Inose M , Higuchi I , Higuchi F , Kondo I . Changes in the supporting muscles of the fractured hip in elderly women . Bone . 2002;30:325–330
  25. Dhesi JK , Bearne LM , Moniz C , et al.   Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status . J Bone Miner Res . 2002;17:891–897
  26. Chapuy MC , Arlot ME , Delmas PD , Meunier PJ . Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women . BMJ . 1994;308:1081–1082
  27. Dawson-Hughes B , Harris SS , Krall EA , Dallal GE . Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older . N Engl J Med . 1997;337:670–676
  28. Bischoff HA , Stahelin HB , Dick W , et al.   Effects of vitamin D and calcium supplementation on falls (a randomized controlled trial) . J Bone Miner Res . 2003;18:343–351
  29. Bischoff-Ferrari HA , Dawson-Hughes B , Willett WC , et al.   Effect of vitamin D on falls (a meta-analysis) . JAMA . 2004;291:1999–2006
  30. Greenspan SL , Resnick NM , Parker RA . Early changes in biochemical markers of bone turnover are associated with long-term changes in bone mineral density in elderly women on alendronate, hormone replacement therapy, or combination therapy (a three-year, double-blind, placebo-controlled, randomized clinical trial) . J Clin Endocrinol Metab . 2005;90:2762–2767
  31. Eastell R , Barton I , Hannon RA , Chines A , Garnero P , Delmas PD . Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate . J Bone Miner Res . 2003;18:1051–1056
  32. Holick MF , Matsuoka LY , Wortsman J . Age, vitamin D, and solar ultraviolet . Lancet . 1989;2:1104–1105
  33. Holick MF . McCollum Award Lecture, 1994 (vitamin D—new horizons for the 21st century) . Am J Clin Nutr . 1994;60:619–630
  34. Institute of Medicine, Food and Nutrition Board . Dietary reference intakes (calcium, phosphorus, magnesium, vitamin D and fluoride) . Washington (DC): Natl Acad Pr; 1999;
  35. In: Dietary reference intakes: applications in dietary assessment. A Report of the Subcommittees on Interpretation and Uses of Dietary Reference Intakes and Upper Reference Levels of Nutrients, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board . Washington (DC): Natl Acad Pr; 2000;p. 106–112
  36. Holick MF , Siris ES , Binkley N , et al.   Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy . J Clin Endocrinol Metab . 2005;90:3215–3224

 Supported by the National Institutes of Health (grant no. M01RR 00533).No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.Reprints are not available from the author.

PII: S0003-9993(06)00287-5

doi: 10.1016/j.apmr.2006.03.009

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 7 , Pages 904-908 , July 2006

Article Tools

* Image Usage & Resolution