Vitamin D Deficiency and Osteoporosis in Rehabilitation Inpatients

Abstract 

Shinchuk LM, Morse L, Huancahuari N, Arum S, Chen TC, Holick MF. Vitamin D deficiency and osteoporosis in rehabilitation inpatients.

Objective

To determine vitamin D status and bone mineral density (BMD) in patients admitted to a subacute rehabilitation facility.

Design

Cross-sectional cohort study.

Setting

Subacute rehabilitation facility.

Participants

Fifty-three community-dwelling patients admitted from June through February 2005.

Interventions

Not applicable.

Main Outcome Measures

BMD, 25-hydroxyvitamin D (25[OH]D), C-telopeptide (CTX), osteocalcin, and dietary milk intake.

Results

Prevalence of vitamin D deficiency (25[OH]D <20ng/mL) was 49.1%, while a total of 83% of patients were either vitamin D deficient or insufficient (25[OH]D <30ng/mL). The prevalence of osteopenia (T score, <−1) was 52.8%; osteoporosis (T score, <−2.5) was 17.0%. CTX (bone resorption marker) was elevated in 60.4% of patients. Osteocalcin (bone formation marker) was elevated in 13.2% of patients. Measurements of bone resorption and formation positively correlated (R²=.22) indicating increased bone remodeling.

Conclusions

Vitamin D deficiency and osteopenia and osteoporosis were highly prevalent in patients admitted for rehabilitation. Elevated bone resorption and remodeling were evident. This could be due to vitamin D deficiency that should be corrected before antiresorptive therapy is considered. The study emphasizes the need for vigilance for vitamin D status and BMD testing in patients admitted to rehabilitation facilities.

Key Words:  Bone density , Osteoporosis , Rehabilitation , Vitamin D deficiency