Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 6 , Pages 793-798 , June 2006

Aggressive Behavior in Patients With Stroke: Association With Psychopathology and Results of Antidepressant Treatment on Aggression

  • Keen-Loong Chan, MD

      Affiliations

    • Department of Psychological Medicine, Tan Tock Seng Hospital, Singapore
    • ,
  • Antonio Campayo, MD

      Affiliations

    • Department of Psychiatry, Hospital Clinico de Zaragoza, Zaragoza, Spain
    • ,
  • David J. Moser, PhD

      Affiliations

    • Department of Psychiatry, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA
    • ,
  • Stephan Arndt, PhD

      Affiliations

    • Department of Psychiatry, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA
    • ,
  • Robert G. Robinson, MD

      Affiliations

    • Department of Psychiatry, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA
    • Corresponding Author InformationReprint requests to Robert G. Robinson, MD, Dept of Psychiatry, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242

  • Image Result

    Change in aggression score as derived from the PSE at the beginning and the end of a 12-week, double-blind treatment trial comparing effectiveness of nortriptyline, fluoxetine, and placebo in treating

    Change in aggression score as derived from the PSE at the beginning and the end of a 12-week, double-blind treatment trial comparing effectiveness of nortriptyline, fluoxetine, and placebo in treating aggression after stroke. Active versus placebo analysis did not show a significant time-by-treatment interaction. Patients who responded to treatment of depression, however, showed a significantly greater decline in aggression scores than did patients who did not respond to treatment (F1,14=5.61, P=.033).

 Supported in part by the National Institutes of Health (grant nos. MH52879, MH53592, MH63405).No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(06)00164-X

doi: 10.1016/j.apmr.2006.02.016

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 6 , Pages 793-798 , June 2006

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