Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 3 , Pages 376-382 , March 2006

Osteoporosis in Adults With Meningomyelocele: An Unrecognized Problem at Rehabilitation Clinics

Presented in part to the VIII Congress of Nordic Medical Society of Paraplegia, September 4−7, 2003, Helsinki, Finland.

  • Kirsi M. Valtonen, MD

      Affiliations

    • Department of Rehabilitation Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • Department of Rehabilitation Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
    • Corresponding Author InformationReprint requests to Kirsi M. Valtonen, MD, Härkävaljakontie 5 B 1, FI-00750 Helsinki, Finland. Reprints are not available from the authors.
  • ,
  • Lars-Åke Goksör, MD

      Affiliations

    • Department of Radiology, Sahlgrenska University Hospital, Göteborg, Sweden
  • ,
  • Olof Jonsson, MD, DMedSc

      Affiliations

    • Department of Urology, Sahlgrenska University Hospital, Göteborg, Sweden
  • ,
  • Dan Mellström, MD, DMedSc

      Affiliations

    • Department of Geriatric Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
  • ,
  • Hannu T. Alaranta, MD, DMedSc

      Affiliations

    • Käpylä Rehabilitation Centre, Helsinki, Finland
  • ,
  • Eira R. Viikari-Juntura, MD, DMedSc

      Affiliations

    • Department of Rehabilitation Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden
    • Department of Rehabilitation Medicine, Sahlgrenska University Hospital, Göteborg, Sweden

,Accepted 1 November 2005.

References 

  1. Hunt GM , Oakeshott P . Outcome in people with spina bifida at age 35 (prospective community based cohort study) . BMJ . 2003;326:1365–1366
  2. Tomlinson P , Sugarman D . Complications with shunts in adults with spina bifida . BMJ . 1995;311:286–287
  3. McDonnell GV , McCann JP . Issues of medical management in adults with spina bifida . Childs Nerv Syst . 2000;16:222–227
  4. Bartonek Å , Saraste H , Samuelsson L , Skoog M . Ambulation in patients with myelomeningocele (a 12-year follow-up) . J Pediatr Orthop . 1999;19:202–206
  5. Kanis JA . Diagnosis of osteoporosis and assessment of fracture risk . Lancet . 2002;359:1929–1936
  6. Abes M , Sarihan H , Madenci E . Evaluation of bone mineral density with dual x-ray absorptiometry for osteoporosis in children with bladder augmentation . J Pediatr Surg . 2003;38:230–232
  7. Farhat G , Yamout B , Mikati MA , Demirjian S , Sawaya R , El-Hajj Fuleihan G . Effect of antiepileptic drugs on bone density in ambulatory patients . Neurology . 2002;58:1348–1353
  8. Quan A , Adams R , Ekmark E , Baum M . Bone mineral density in children with myelomeningocele . Pediatrics . 1998;102:E34
  9. Rosenstein BD , Greene WB , Herrington RT , Blum AS . Bone density in myelomeningocele (the effects of ambulatory status and other factors) . Dev Med Child Neurol . 1987;29:486–494
  10. Koch MO , McDougal WS , Hall MC , Hill DE , Braren HV , Donofrio MN . Long-term metabolic effects of urinary diversion (a comparison of myelomeningocele patients managed by clean intermittent catheterization and urinary diversion) . J Urol . 1992;147:1343–1347
  11. Mingin GC , Nguyen HT , Mathias RS , Shepherd JA , Glidden D , Baskin LS . Growth and metabolic consequences of bladder augmentation in children with myelomeningocele and bladder exstrophy . Pediatrics . 2002;110:1193–1198
  12. Maynard FM , Bracken MB , Creasey G , et al.  American Spinal Injury Association   International Standards for Neurological and Functional Classification of Spinal Cord Injury . Spinal Cord . 1997;35:266–274
  13. Hultling C , Levi R , Amark SP , Sjöblom P . Semen retrieval and analysis in men with myelomeningocele . Dev Med Child Neurol . 2000;42:681–684
  14. Hoffer MM , Feiwell E , Perry R , Perry J , Bonnett C . Functional ambulation in patients with myelomeningocele . J Bone Joint Surg Am . 1973;55:137–148
  15. Lazner F , Gowen M , Pavasovic D , Kola I . Osteopetrosis and osteoporosis (two sides of the same coin) . Hum Mol Genet . 1999;8:1839–1846
  16. Kannisto M , Alaranta H , Merikanto J , Kröger H , Kärkkäinen J . Bone mineral status after pediatric spinal cord injury . Spinal Cord . 1998;36:641–646
  17. Fiore P , Picco P , Castagnola E , et al.   Nutritional survey of children and adolescents with myelomeningocele (MMC) (overweight associated with reduced energy intake) . Eur J Pediatr Surg . 1998;8(Suppl 1):34–36
  18. Boonen S , Rizzoli R , Meunier PJ , et al.   The need for clinical guidance in the use of calcium and vitamin D in the management of osteoporosis (a consensus report) . Osteoporos Int . 2004;15:511–519
  19. Henderson RC , Lark RK , Kecskemethy HH , Miller F , Harcke HT , Bachrach SJ . Bisphosphonates to treat osteopenia in children with quadriplegic cerebral palsy (a randomized, placebo-controlled clinical trial) . J Pediatr . 2002;141:644–651
  20. Sniger W , Garshick E . Alendronate increases bone density in chronic spinal cord injury (a case report) . Arch Phys Med Rehabil . 2002;83:139–140
  21. Zehnder Y , Risi S , Michel D , et al.   Prevention of bone loss in paraplegics over 2 years with alendronate . J Bone Miner Res . 2004;19:1067–1074
  22. Mehta NM , Malootian A , Gilligan JP . Calcitonin for osteoporosis and bone pain . Curr Pharm Des . 2003;9:2659–2676
  23. Quattrocchi E , Kourlas H . Teriparatide (a review) . Clin Ther . 2004;26:841–854
  24. Sakai A , Sakata T , Ikeda S , et al.   Intermittent administration of human parathyroid hormone (1-34) prevents immobilization-related bone loss by regulating bone marrow capacity for bone cells in ddY mice . J Bone Miner Res . 1999;14:1691–1699
  25. Legroux-Gerot I , Catanzariti L , Marchandise X , Duquesnoy B , Cortet B . Bone mineral density changes in hypercalciuretic osteoporotic men treated with thiazide diuretics . Joint Bone Spine . 2004;71:51–55
  26. Quan A , Adams R , Ekmark E , Baum M . Bone mineral density in children with myelomeningocele (effect of hydrochlorothiazide) . Pediatr Nephrol . 2003;18:929–933
  27. Caulton JM , Ward KA , Alsop CW , Dunn G , Adams JE , Mughal MZ . A randomised controlled trial of standing programme on bone mineral density in non-ambulant children with cerebral palsy . Arch Dis Child . 2004;89:131–135
  28. Kunkel CF , Scremin AM , Eisenberg B , Garcia JF , Roberts S , Martinez S . Effect of “standing” on spasticity, contracture, and osteoporosis in paralyzed males . Arch Phys Med Rehabil . 1993;74:73–78
  29. Belanger M , Stein RB , Wheeler GD , Gordon T , Leduc B . Electrical stimulation (can it increase muscle strength and reverse osteopenia in spinal cord individuals?) . Arch Phys Med Rehabil . 2000;81:1090–1098

 No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

PII: S0003-9993(05)01382-1

doi: 10.1016/j.apmr.2005.11.004

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 3 , Pages 376-382 , March 2006