Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 2 , Pages 229-234 , February 2006

Effects of Treadmill Exercise on Transcranial Magnetic Stimulation−Induced Excitability to Quadriceps After Stroke

  • Larry W. Forrester, PhD

      Affiliations

    • Baltimore Veterans Affairs Medical Center Rehabilitation Research Service, Baltimore, MD
    • Department of Physical Therapy & Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD
    • Department of Neurology, University of Maryland School of Medicine, Baltimore, MD
    • Corresponding Author InformationReprint requests to Larry W. Forrester, PhD, Dept of Physical Therapy & Rehabilitation Science, University of Maryland School of Medicine, 100 Penn St, Baltimore, MD 21201-1082
    • ,
  • Daniel F. Hanley, MD

      Affiliations

    • Department of Neurology, University of Maryland School of Medicine, Baltimore, MD
    • Division of Brain Injury Outcome, Department of Neurology, Johns Hopkins University, Baltimore, MD
    • ,
  • Richard F. Macko, MD

      Affiliations

    • Department of Neurology, University of Maryland School of Medicine, Baltimore, MD
    • Department of Medicine, Divisions of Gerontology and Rehabilitation Medicine, University of Maryland School of Medicine, Baltimore, MD
    • Department of Geriatric Research, Education and Clinical Center, Baltimore, MD

  • Image Result

    Patient positioned for isometric testing of knee extension. Surface electromyography electrodes placed over the vastus medialis muscles bilaterally for recording TMS MEP responses. Visual feedback of

    Patient positioned for isometric testing of knee extension. Surface electromyography electrodes placed over the vastus medialis muscles bilaterally for recording TMS MEP responses. Visual feedback of knee extensor force output presented on computer monitor. Abbreviations: A-to-D, analog to digital; EMG, electromyography; PC, personal computer; TTL synch, transistor-transistor logic synchronization signal.

  • Image Result
    Means ± standard error of pretreadmill exercise comparison of MEPs between nonparetic (NP) and paretic (P) vastus medialis showing lower amplitudes and longer latencies on the paretic side. Data poole

    Means ± standard error of pretreadmill exercise comparison of MEPs between nonparetic (NP) and paretic (P) vastus medialis showing lower amplitudes and longer latencies on the paretic side. Data pooled for all subjects (n=11). *P<.01.

  • Image Result
    Examples of 10 averaged TMS-induced MEPs at vastus medialis before and after a single session of treadmill walking exercise. Top 4 panels show trained patient’s nonparetic and paretic responses. Lower

    Examples of 10 averaged TMS-induced MEPs at vastus medialis before and after a single session of treadmill walking exercise. Top 4 panels show trained patient’s nonparetic and paretic responses. Lower 4 panels show responses of an untrained patient. Arrows denote stimulus onset. Abbreviation: TM, treadmill.

 Supported by the Veterans Affairs (VA) Rehabilitation Research and Development (career development award no. B2375V), National Stroke Association, National Institutes of Health (grant no. R29 AG14487), National Institute on Aging, Claude D. Pepper Older Americans Independence Center (grant no. P60AG 12583), and the Baltimore VA Geriatrics Research, Education & Clinical Center.No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

PII: S0003-9993(05)01330-4

doi: 10.1016/j.apmr.2005.10.016

Archives of Physical Medicine and Rehabilitation
Volume 87, Issue 2 , Pages 229-234 , February 2006

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