Archives of Physical Medicine and Rehabilitation
Volume 86, Issue 12, Supplement , Pages 73-81 , December 2005

An Exploration of Central Nervous System Medication Use and Outcomes in Stroke Rehabilitation

  • Brendan Conroy, MD

      Affiliations

    • Stroke Recovery Program, National Rehabilitation Hospital, Washington, DC
    • ,
  • Richard Zorowitz, MD

      Affiliations

    • Department of Rehabilitation Medicine, University of Pennsylvania Medical Center, Philadelphia, PA
    • ,
  • Susan D. Horn, PhD

      Affiliations

    • International Severity Information Systems Inc and Institute for Clinical Outcomes Research, Salt Lake City, UT
    • Corresponding Author InformationReprint requests to Susan D. Horn, PhD, Institute for Clinical Outcomes Research, 699 E South Temple, Ste 100, Salt Lake City, UT 84102-1282
    • ,
  • David K. Ryser, MD

      Affiliations

    • Division of Physical Medicine and Rehabilitation, Neuro Specialty Rehabilitation Unit, LDS Hospital, Salt Lake City, UT
    • ,
  • Jeff Teraoka, MD

      Affiliations

    • Division of Physical Medicine and Rehabilitation, Stanford University, Palo Alto, CA
    • ,
  • Randall J. Smout, MS

      Affiliations

    • International Severity Information Systems Inc and Institute for Clinical Outcomes Research, Salt Lake City, UT

References 

  1. DeJong G , Horn S , Conroy B , Nichols D , Healton EB . Opening the black box of post-stroke rehabilitation (stroke rehabilitation patients, processes, and outcomes) . Arch Phys Med Rehabil . 2005;86(12 Suppl 2):S1–S7
  2. Medicare Payment Advisory Commission . In: A data book (healthcare spending and the Medicare program) . Washington (DC): MedPAC; 2005;p. 150
  3. Duncan PW , Horner RD , Reker DM , et al.   Adherence to post acute rehabilitation guidelines is associated with functional recovery . Stroke . 2002;33:167–178
  4. Buchanan JL , Rumpel JD , Hoenig H . Charges for outpatient rehabilitation (growth and differences in provider types) . Arch Phys Med Rehabil . 1996;77:320–328
  5. Gresham GE , Duncan PW , Stason WB , et al.   Post-stroke rehabilitation (priorities for future research) . Clinical practice guideline no. 16 . Rockville: U.S. Department of Health and Human Services, Agency for Health Care Policy and Research; 1995; AHCPR Publication No. 95-0062
  6. Carota A , Staub F , Bogousslavsky J . Emotions, behaviours and mood changes in stroke . Curr Opin Neurol . 2002;15(1):57–69
  7. Bogousslavsky J . William Feinberg lecture 2002 (emotions, mood, and behavior after stroke) . Stroke . 2003;34:1046–1050
  8. Starkstein SE , Robinson RG . Affective disorders and cerebral vascular disease . Br J Psychiatry . 1989;154:170–182
  9. Narushima K , Robinson RG . Stroke-related depression . Curr Atheroscler Rep . 2002;4:296–303
  10. Fruehwald S , Gatterbauer E , Rehak P , Baumhackl U . Early fluoxetine treatment of post-stroke depression—a three-month double-blind placebo-controlled study with an open-label long-term follow up . J Neurol . 2003;250:347–351
  11. Gupta A , Pansari K , Shetty H . Post-stroke depression . Int J Clin Pract . 2002;56:531–537
  12. Turner-Stokes L , Hassan N . Depression after stroke (a review of the evidence base to inform the development of an integrated care pathway. Part 2: treatment alternatives) . Clin Rehabil . 2002;16:248–260
  13. Paolucci S , Antonucci G , Grasso MG , et al.  A case-control study   Post-stroke depression, antidepressant treatment and rehabilitation results . Cerebrovasc Dis . 2001;12:264–271
  14. Gall A . Post stroke depression . Hosp Med . 2001;62:268–273
  15. Cole MG , Elie LM , McCusker J , Bellavance F , Mansour A . Feasibility and effectiveness of treatments for post-stroke depression in elderly inpatients (systematic review) . J Geriatr Psychiatry Neurol . 2001;14:37–41
  16. Khan F . Post stroke depression . Aust Fam Physician . 2004;33:831–834
  17. Goldstein LB . Pharmacology of recovery after stroke . Stroke . 1990;21(11 Suppl):III139–III142
  18. Horn SD . Limiting access to psychiatric services can increase total health care costs . Drug Benefit Trends . 2003;15(Suppl 1):12–18
  19. Henon H , Pasquier F , Durieu  , Godefroy O . Preexisting dementia in stroke patients . Stroke . 1997;28:2429–2436
  20. Goldstein LB  The Sygen In Acute Stroke Study Investigators . Common drugs may influence motor recovery after stroke . Neurology . 1995;45:865–871
  21. Gassaway J , Horn SD , DeJong G , Smout RJ , Clark C , James R . Applying the clinical practice improvement approach to stroke rehabilitation (methods used and baseline results) . Arch Phys Med Rehabil . 2005;86(12 Suppl 2):S16–S33
  22. Maulden S , Gassaway J , Horn SD , Smout RJ , DeJong G . Timing of initiation of rehabilitation after stroke . Arch Phys Med Rehabil . 2005;86(12 Suppl 2):S34–S40
  23. Horn SD , Sharkey PD , Gassaway J . Managed Care Outcomes Project (study design, baseline patient characteristics, and outcome measures) . Am J Managed Care . 1996;2:237–247
  24. Horn SD , Sharkey PD , Buckle JM , Backofen JE , Averill RF , Horn RA . The relationship between severity of illness and hospital length of stay and mortality . Med Care . 1991;29:305–317
  25. Averill RF , McGuire TE , Manning BE , et al.   A study of the relationship between severity of illness and hospital cost in New Jersey hospitals . Health Serv Res . 1992;27:587–606 ; discussion 607-12
  26. Thomas TJ , Ashcraft ML . Measuring severity of illness (comparison of severity and severity systems in terms of ability to explain variation in costs) . Inquiry . 1991;28:39–55
  27. Alemi F , Rice J , Hankins R . Predicting in-hospital survival of myocardial infarction, a comparative study of various severity measures . Med Care . 1990;28:762–774
  28. Epocrates Inc. Available at: http://www2.epocrates.com. Accessed September 4, 2005
  29. In:  Hart AC ,  Schmidt KM ,  Aaron WS editor. ICD-9-CM code book . Reston: St. Anthony’s Publishing; 1999;
  30. Feeney DM , Gonzalez A , Law WA . Amphetamine, haloperidol and experience interact to affect the rate of recovery after motor cortex injury . Science . 1982;217:885–887
  31. Hovda DA , Feeney DM . Amphetamine with experience promotes recovery of locomotor function after unilateral frontal cortex injury in the cat . Brain Res . 1984;298:358–361
  32. Evans RW , Gualtieri CT , Patterson D . Treatment of chronic closed head injury with psychostimulant drugs (a controlled case study and an appropriate evaluation procedure) . J Nerv Ment Dis . 1987;175:106–110
  33. Gualtieri CT . Pharmacotherapy and the neurobehavioural sequelae of traumatic brain injury . Brain Inj . 1988;2:101–129
  34. Gualtieri CT , Chandler M , Coons TB , Brown LT . Amantadine (a new clinical profile for traumatic brain injury) . Clin Neuropharmacol . 1989;12:258–270
  35. Kraus MF , Maki P . Combined use of amantadine and L-dopa/carbidopa in the treatment of chronic brain injury . Brain Inj . 1997;11:455–460
  36. Nickels JL , Schneider WN , Dombovy ML , Wong TM . Clinical use of amantadine in brain injury rehabilitation . Brain Inj . 1994;8:709–718
  37. Tillerson JL , Cohen AD , Philhower J , Miller GW , Zigmond MJ , Schallert T . Forced limb use effects on the behavioral and neurochemical effects of 6-hydroxydopamine . J Neurosci . 2001;21:4427–4435
  38. Mukand JA , Guilmette TJ , Allen DG , et al.   Dopaminergic therapy with carbidopa L-dopa for left neglect after stroke . Arch Phys Med Rehabil . 2001;82:1279–1282
  39. Kujac TL , Thomander D , Teraoka JK . Efficacy of amantadine in facilitating cognitive recovery in stroke patients [abstract] . Arch Phys Med Rehabil . 2001;82:1342
  40. Scheidtmann K , Fries W , Muller F , Koenig E . Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke (a prospective, randomized, double-blind study) . Lancet . 2001;358:787–790
  41. Martinsson L , Wahlgren NG , Hardemark HG . Amphetamines for improving recovery after stroke . Cochrane Database Syst Rev . 2003;3: CD002090
  42. Baezner H , Oster M , Henning O , Cohen S , Hennerici MG . Amantadine increases gait steadiness in frontal gait disorder due to subcortical vascular encephalopathy (a double-blind randomized placebo-controlled trial based on quantitative gait analyses) . Cerebrovasc Dis . 2001;11:235–244
  43. Grade C , Redford B , Chrostowski J , Toussaint L , Blackwell B . Methylphenidate in early post stroke recovery (a double-blind, placebo-controlled study) . Arch Phys Med Rehabil . 1998;79:1047–1050
  44. Meltzer HY . Beyond control of acute exacerbation (enhancing affective and cognitive outcomes) . CNS Spectr . 2003;8(11 Suppl 2):16–18 , 22
  45. Gur RE , Kohler C , Ragland JD , et al.   Neurocognitive performance and clinical changes in olanzapine-treated patients with schizophrenia . Neuropsychopharmacology . 2003;28:2029–2036
  46. Tyson PJ , Roberts KH , Mortimer AM . Are the cognitive effects of atypical anti-psychotics influenced by their affinity to 5HT-2A receptors? . Int J Neurosci . 2004;114:593–611
  47. U.S. Food and Drug Administration Center for Drug Evaluation and Research . FDA public health advisory (deaths with antipsychotics in elderly patients with behavioral disturbances) . 2005; April 11, Available at: http://www.fda.gov/cder/drug/advisory/antipsychotics.htm. Accessed September 4, 2005
  48. Horn SD , Sharkey PD , Tracy DM , Horn CE , James B , Goodwin F . Intended and unintended consequences of HMO cost-containment strategies (results from the Managed Care Outcomes Project) . Am J Managed Care . 1996;2:253–264

 Supported by the National Institute on Disability and Rehabilitation Research (grant no. H133B990005) and the U.S. Army and Materiel Command (cooperative agreement award no. DAMD17-02-2-0032). The views, opinions, and/or findings contained in this article are those of the author(s) and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation.No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

PII: S0003-9993(05)01197-4

doi: 10.1016/j.apmr.2005.08.129

Archives of Physical Medicine and Rehabilitation
Volume 86, Issue 12, Supplement , Pages 73-81 , December 2005

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